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We previously showed that the structure of \u03b1\u2010NaTx specificity module responsible for selective Na\n                    <jats:sub>v<\/jats:sub>\n                    binding is governed by an interplay between the nest and niche protein motifs. Here, we report the solution structure of the toxin Lqq4 from the venom of the scorpion\n                    <jats:italic>Leiurus\u2009quinquestriatus<\/jats:italic>\n                    . Unexpectedly, we find that this toxin presents an ensemble of long\u2010lived structurally distinct states. We unequivocally assign these states to the alternative configurations (\n                    <jats:italic>cis<\/jats:italic>\n                    \u2013\n                    <jats:italic>trans<\/jats:italic>\n                    isomers) of two peptide bonds: V56\u2013P57 and C17\u2013G18; neither of the\n                    <jats:italic>cis<\/jats:italic>\n                    isomers has been described in \u03b1\u2010NaTx so far. We argue that the native conformational space of \u03b1\u2010NaTx is wider than assumed previously.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14705","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T01:26:39Z","timestamp":1690507599000},"page":"2358-2368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A scorpion toxin affecting sodium channels shows double\n                    <i>cis<\/i>\n                    \u2013\n                    <i>trans<\/i>\n                    isomerism"],"prefix":"10.1002","volume":"597","author":[{"given":"Konstantin S.","family":"Mineev","sequence":"first","affiliation":[{"name":"Shemyakin\u2010Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikhail 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