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Perturbation of protein kinase signalling underlies the development of some of these disorders. For example, disrupted SRPK signalling is associated with intellectual disabilities, and the gene dosage of DYRKs can dictate the pathology of disorders including Down's syndrome. Here, we review the emerging roles of the CMGC kinase families SRPK, CLK, DYRK, and sub\u2010family HIPK during embryonic development and in developmental disorders. In particular, SRPK, CLK, and DYRK kinase families have key roles in developmental signalling and stem cell regulation, and can co\u2010ordinate neuronal development and function. Genetic studies in model organisms reveal critical phenotypes including embryonic lethality, sterility, musculoskeletal errors, and most notably, altered neurological behaviours arising from defects of the neuroectoderm and altered neuronal signalling. Further unpicking the mechanisms of specific kinases using human stem cell models of neuronal differentiation and function will improve our understanding of human developmental disorders and may provide avenues for therapeutic strategies.<\/jats:p>","DOI":"10.1002\/1873-3468.14723","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:04:18Z","timestamp":1692734658000},"page":"2375-2415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Functions of<scp>SRPK<\/scp>,<scp>CLK<\/scp>and<scp>DYRK<\/scp>kinases in stem cells, development, and human developmental disorders"],"prefix":"10.1002","volume":"597","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-3202","authenticated-orcid":false,"given":"Elizabeth K. 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