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Although hypertension is manageable by medication and lifestyle changes, the risk increases with age. In an increasingly aged society, the incidence of hypertension is escalating, and is expected to increase the prevalence of (cerebro)vascular events and their associated mortality. Adherence to plant\u2010based diets improves blood pressure and vascular markers in individuals with hypertension. Food flavonoids have an inhibitory effect towards angiotensin\u2010converting enzyme (ACE1) and although this effect is greatly diminished upon metabolization, their microbial metabolites have been found to improve endothelial nitric oxide synthase (eNOS) activity. Considering the transmembrane location of ACE1 and eNOS, the ability of (poly)phenols to interact with membrane lipids modulate the cell membrane's biophysical properties and impact on nitric oxide (<jats:sup>\u00b7<\/jats:sup>NO) synthesis and bioavailability, remain poorly studied. Herein, we provide an overview of the current knowledge on the lipid remodeling of endothelial membranes with age, its impact on the cell membrane's biophysical properties and <jats:sup>\u00b7<\/jats:sup>NO permeability across the endothelial barrier. We also discuss the potential of (poly)phenols and other plant\u2010based compounds as key players in hypertension management, and address the caveats and challenges in adopted methodologies.<\/jats:p>","DOI":"10.1002\/1873-3468.14812","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T02:03:25Z","timestamp":1706493805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dietary (poly)phenols as modulators of the biophysical properties in endothelial cell membranes: its impact on nitric oxide bioavailability in hypertension"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-9902","authenticated-orcid":false,"given":"Ana","family":"Reis","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias Universidade do Porto  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-8806","authenticated-orcid":false,"given":"Barbara S.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Center for Neuroscience and Cell Biology University of Coimbra, Polo das Ci\u00eancias da Sa\u00fade  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Laranjinha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Center for Neuroscience and Cell Biology University of Coimbra, Polo das Ci\u00eancias da Sa\u00fade  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"de Freitas","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias Universidade do Porto  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)01330-1","article-title":"Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population\u2010representative studies with 104 million participants","volume":"398","author":"Zhou B","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_9_3_1","first-page":"3028","article-title":"European heart network, Brussels","volume":"34","author":"Wilkins E","year":"2017","journal-title":"Eur Cardiovasc Dis Stat"},{"key":"e_1_2_9_4_1","volume-title":"Textbook of Medical Physiology","author":"Guyton AC","year":"2006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1242\/jcs.119628","article-title":"Endothelial cell and model membranes respond to shear stress 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