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To achieve this, cancer cells need large amounts of lipids to build membranes, synthesize lipid\u2010derived molecules, and generate metabolic energy in the absence of other nutrients. Tumor cells potentiate strategies to obtain lipids from other cells, metabolic pathways to synthesize new lipids, and mechanisms for efficient storage, mobilization, and utilization of these lipids. Lipid droplets (LDs) are the organelles that collect and supply lipids in eukaryotes and it is increasingly recognized that the accumulation of\u00a0LDs is a new hallmark of cancer cells. Furthermore, an active role of LD proteins in processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes of LD\u2010resident proteins (perilipins, lipases, and acyl\u2010CoA synthetases), we provide an overview of the contribution of LDs to cancer progression and discuss the role of LD proteins during the proliferation, invasion, metastasis, apoptosis, and stemness of cancer cells.<\/jats:p>","DOI":"10.1002\/1873-3468.14820","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T20:30:05Z","timestamp":1707337805000},"page":"1301-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Lipid droplets provide metabolic flexibility for cancer progression"],"prefix":"10.1002","volume":"598","author":[{"given":"R\u00e9mi","family":"Safi","sequence":"first","affiliation":[{"name":"Josep Carreras Leukemia Research Institute  Barcelona Spain"},{"name":"Lipid Trafficking and Disease Group Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer 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