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Achieving complete eradication of the virus remains a formidable challenge. Cytotoxic T lymphocytes, specific to viral antigens, either exhibit a numerical deficiency or succumb to an exhausted state in individuals chronically afflicted with HBV. The comprehension of the genesis and dissemination of stem cell memory T cells (TSCMs) targeting HBV remains inadequately elucidated. We identified TSCMs in subjects with chronic HBV infection and scrutinized their efficacy in a murine model with human hepatocyte transplants, specifically the TK\u2010NOG mice. TSCMs were discerned in all subjects under examination. Introduction of TSCMs into the HBV mouse model precipitated a severe necro\u2010inflammatory response, resulting in the elimination of human hepatocytes. TSCMs may constitute a valuable tool in the pursuit of a remedial therapy for HBV infection.<\/jats:p>","DOI":"10.1002\/1873-3468.14842","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T22:00:20Z","timestamp":1712700020000},"page":"1354-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis B virus\u2010specific human stem cell memory T cells differentiate into cytotoxic T cells and eradicate\n                    <scp>HBV<\/scp>\n                    \u2010infected hepatocytes in mice"],"prefix":"10.1002","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7665-900X","authenticated-orcid":false,"given":"Hiromi","family":"Abe\u2010Chayama","sequence":"first","affiliation":[{"name":"Center for Medical Specialist Graduate Education and Research, Graduate School of Biomedical and Health Sciences Hiroshima University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takakazu","family":"Kawase","sequence":"additional","affiliation":[{"name":"Department of Immune Regenerative Medicine, International Center for Cell and Gene Therapy Fujita Health University  Toyoake Japan"},{"name":"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine (RIRBM) Hiroshima University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine (RIRBM) Hiroshima University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Ishida","sequence":"additional","affiliation":[{"name":"PhoenixBio Co., Ltd.  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