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The present study identified the expression of a defective retroviral\n                    <jats:italic>env<\/jats:italic>\n                    gene belonging to the ERV group V member Env (EnvV) in\n                    <jats:italic>Felis\u2009catus<\/jats:italic>\n                    (EnvV\u2010Fca). EnV\u2010Fca was specifically detected in the placental trophoblast syncytiotrophobic layer and expressed as a secreted protein in cultured cells. Genetic analyses indicated that EnvV2 genes are widely present in vertebrates and are under purifying selection among carnivores, suggesting a potential benefit for the host. This study suggests that birds, bats, and rodents carrying EnvV2 may play significant roles as intermediate vectors in spreading or cross\u2010transmitting viruses among species. Our findings provide valuable insights into the evolution of ERV in vertebrate hosts.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14873","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T22:50:03Z","timestamp":1712875803000},"page":"1792-1806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of the endogenous retrovirus\u2010derived placenta\u2010specific soluble protein\n                    <scp>E<\/scp>\n                    nv\n                    <scp>V<\/scp>\n                    \u2010\n                    <scp>F<\/scp>\n                    ca from domestic cats"],"prefix":"10.1002","volume":"598","author":[{"given":"Didik","family":"Pramono","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology and Infectious Disease, Joint Graduate School of Veterinary Medicine Yamaguchi University  Japan"},{"name":"Research Institute for Cell Design Medical Science Yamaguchi University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Infectious Disease, Joint Graduate School of Veterinary Medicine Yamaguchi University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Kimura","sequence":"additional","affiliation":[{"name":"The Joint Graduate School of Veterinary Medicine Yamaguchi University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariko","family":"Miyake","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Infectious Disease, Joint Graduate School of Veterinary Medicine Yamaguchi University  Japan"},{"name":"Research Institute for Cell Design Medical Science Yamaguchi University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-2137","authenticated-orcid":false,"given":"Kazuo","family":"Nishigaki","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology and Infectious Disease, Joint Graduate School of Veterinary Medicine Yamaguchi University  Japan"},{"name":"Research Institute for Cell Design Medical Science Yamaguchi University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"335","volume-title":"Retroviruses","author":"Coffin JM","year":"1997"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35057062"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6380007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01262"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi088"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2072"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704313104"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(88)90035-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012374410-4.00428-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03653-14"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113065"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2114441119"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55933-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01267-13"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq7871"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01462"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/35001608"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-8-266"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-2-19"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003400"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010458"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-36-1-59"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/275656a0"},{"key":"e_1_2_9_25_1","unstructured":"BeltzGA MarcianiDJ HungC\u2010HandKensilCA(1994)Vaccine comprising recombinant feline leukemia antigen and saponin adjuvant. 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