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Mitochondrial E3 ubiquitin ligase 1 (Mul1) localizes to the mitochondrial outer membrane. We found that female Mul1\u2010deficient mice are infertile, and\u00a0their oocytes contain high ROS concentrations. After fertilization, Mul1\u2010deficient embryos showed a DNA damage response (DDR) and abnormal preimplantation embryogenesis, which was rescued by NAC addition and ROS depletion. These observations clearly demonstrate that loss of Mul1 in oocytes increases ROS concentrations and triggers DDR, resulting in abnormal preimplantation embryogenesis. We conclude that manipulating the mitochondrial ROS levels in oocytes may be a potential therapeutic approach to target infertility.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14876","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T10:43:56Z","timestamp":1713523436000},"page":"1740-1752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased\n                    <scp>ROS<\/scp>\n                    levels in mitochondrial outer membrane protein Mul1\u2010deficient oocytes result in abnormal preimplantation embryogenesis"],"prefix":"10.1002","volume":"598","author":[{"given":"Ann","family":"Nakai","sequence":"first","affiliation":[{"name":"Department of Biological Science, Graduate School of Humanities and Sciences Nara Women's University  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