{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:59:01Z","timestamp":1780520341894,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["NARI\/SAC\/Intra\/2022\u201023\/2266"],"award-info":[{"award-number":["NARI\/SAC\/Intra\/2022\u201023\/2266"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:p>\n                    Nanotechnology offers promising avenues for enhancing drug delivery systems, particularly in HIV\u20101 treatment. This study investigates a nanoemulsified formulation combining epigallocatechin gallate (EGCG) with dolutegravir (DTG) for managing HIV\u20101 infection. The combinatorial interaction between EGCG and DTG was explored through cellular, enzymatic, and molecular studies.\n                    <jats:italic>In\u2009vitro<\/jats:italic>\n                    assays demonstrated the potential of a dual drug\u2010loaded nanoemulsion, NE\u2010DTG\u2010EGCG, in inhibiting HIV\u20101 replication, with EGCG serving as a supplementary treatment containing DTG.\n                    <jats:italic>In\u2009silico<\/jats:italic>\n                    molecular interaction studies highlighted EGCG's multifaceted inhibitory potential against HIV\u20101 integrase and reverse transcriptase enzymes. Further investigations are needed to validate the formulation's efficacy across diverse contexts. Overall, by integrating nanotechnology into drug delivery systems, this study represents a significant advancement in managing HIV\u20101 infection.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14936","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T22:25:11Z","timestamp":1716589511000},"page":"1919-1936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A nanoemulsified formulation of dolutegravir and epigallocatechin gallate inhibits HIV\u20101 replication in cellular models"],"prefix":"10.1002","volume":"598","author":[{"given":"Shraddha Y.","family":"Gaikwad","sequence":"first","affiliation":[{"name":"Division of Virology ICMR\u2010National AIDS Research Institute  Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Meerut 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