{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:58:37Z","timestamp":1791874717094,"version":"4.3.4"},"reference-count":104,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014434","name":"Narodowa Agencja Wymiany Akademickiej","doi-asserted-by":"publisher","award":["PPN\/PPO\/2019\/1\/00035\/U\/0001"],"award-info":[{"award-number":["PPN\/PPO\/2019\/1\/00035\/U\/0001"]}],"id":[{"id":"10.13039\/501100014434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/30\/E\/NZ3\/00624"],"award-info":[{"award-number":["2018\/30\/E\/NZ3\/00624"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/37\/B\/NZ3\/03633"],"award-info":[{"award-number":["2020\/37\/B\/NZ3\/03633"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>The hypothalamic\u2013pituitary axis is central to the functioning of the neuroendocrine system and essential for regulating physiological and behavioral homeostasis and coordinating fundamental body functions. The expanding line of evidence shows the indispensable role of the microRNA pathway in regulating the gene expression profile in the developing and adult hypothalamus and pituitary gland. Experiments provoking a depletion of miRNA maturation in the context of the hypothalamic\u2013pituitary axis brought into focus a prominent involvement of miRNAs in neuroendocrine functions. There are also a few individual miRNAs and miRNA families that have been studied in depth revealing their crucial role in mediating the regulation of fundamental processes such as temporal precision of puberty timing, hormone production, fertility and reproduction capacity, and energy balance. Among these miRNAs, miR\u20107 was shown to be hypothalamus\u2010enriched and the top one highly expressed in the pituitary gland, where it has a profound impact on gene expression regulation. Here, we review miRNA profiles, knockout phenotypes, and miRNA interaction (targets) in the hypothalamic\u2013pituitary axis that advance our understanding of the roles of miRNAs in mammalian neurosecretion and related physiology.<\/jats:p>","DOI":"10.1002\/1873-3468.14948","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T21:45:24Z","timestamp":1718055924000},"page":"1557-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Micromanaging the neuroendocrine system \u2013 A review on\n                    <scp>miR<\/scp>\n                    \u20107 and the other physiologically relevant\n                    <scp>miRNAs<\/scp>\n                    in the hypothalamic\u2013pituitary axis"],"prefix":"10.1002","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-7070","authenticated-orcid":false,"given":"Julian","family":"Zacharjasz","sequence":"first","affiliation":[{"name":"Department of Non\u2010coding RNAs Institute of Bioorganic Chemistry, Polish Academy of Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sztachera","sequence":"additional","affiliation":[{"name":"Department of Non\u2010coding RNAs Institute of Bioorganic Chemistry, Polish Academy of Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Smuszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Non\u2010coding RNAs Institute of Bioorganic Chemistry, Polish Academy of Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-6577","authenticated-orcid":false,"given":"Monika","family":"Piwecka","sequence":"additional","affiliation":[{"name":"Department of Non\u2010coding RNAs Institute of Bioorganic Chemistry, Polish Academy of Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101206"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470015902.a0000176.pub3"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.629"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1152"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2100052118"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5324"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00657-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf6251"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0045-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.040"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw116"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002277117"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx706"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0265-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3947"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.249201.119"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.783108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-022-00467-7"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24896"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-017-0149-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-021-08003-4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.05.033"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2020.104890"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180233"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.130521"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00090"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605781103"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4298"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1770"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2018.1451720"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4238\/2012.October.2.2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141020326"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024883"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057156"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0370-x"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4767-x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.747100"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10030402"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.03.155"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-10-90"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.01.021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-022-09703-7"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.11.002"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ18-0487"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.748152"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1253"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1953310"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.126441"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002823"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.10.006"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2012.10.001"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1344"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32347-4"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1285-z"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02283-6"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0509"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08170"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.062"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/695214"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73066"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.04.003"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3142"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.199190.112"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8526"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.05.022"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02358.x"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90031"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa220"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33367-w"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1618-y"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00097"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110969"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237999"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.12.016"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.68"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108946"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.075"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101507"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006247"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.636220"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4251-13.2014"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.08.005"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.292722"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20190788"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302160"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-14-0315"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000532"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03076"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810550106"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.425504"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0001"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10112"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.40429"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46427-0"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-019-0250-9"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30070"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065300"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C113.541417"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.075"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12308"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2014.5"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.621565"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.14948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T11:02:52Z","timestamp":1720436572000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.14948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":104,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/1873-3468.14948"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.14948","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"assertion":[{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}