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Microglial activation and inflammation play essential roles in photoreceptor degeneration in RP, although the underlying mechanisms remain unclear. Here, we examined the progressive degeneration of photoreceptors in\n                    <jats:italic>rd1<\/jats:italic>\n                    mice, a mouse model of RP. We investigated the molecular changes in various retinal cells in\n                    <jats:italic>rd1<\/jats:italic>\n                    mice using single\u2010cell RNA sequencing and found that potentiation of JNK signaling is associated with photoreceptor degeneration in RP. Moreover, inflammation\u2010related molecules, which function downstream of JNK, are elevated in RP. Furthermore, inhibiting JNK alleviates microglial activation and rescues photoreceptor degeneration in\n                    <jats:italic>rd1<\/jats:italic>\n                    mice. Thus, our findings suggest that targeting JNK is a promising approach for slowing RP progression.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14978","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:51:16Z","timestamp":1721091076000},"page":"2683-2701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of\n                    <scp>JNK<\/scp>\n                    ameliorates rod photoreceptor degeneration in a mouse model of retinitis pigmentosa"],"prefix":"10.1002","volume":"598","author":[{"given":"Chunyan","family":"Liao","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen 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