{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:54:26Z","timestamp":1791654866049,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16644"],"award-info":[{"award-number":["22K16644"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2123"],"award-info":[{"award-number":["JPMJSP2123"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    Skeletal muscle atrophy is a known risk factor for immunosuppressive conditions and for a poor prognosis in sepsis. However, its immunopathology has not been experimentally elucidated. This study investigated the effects of skeletal muscle atrophy on the immunopathology of sepsis. Male C57BL\/6J mice were subjected to sciatic denervation (DN) and caecal ligation and puncture (CLP) to induce muscle atrophy or sepsis. The macrophages, myeloid\u2010derived suppressor cells (MDSC), and T\u2010cells in peritoneal and spleen were analysed using flow cytometry. DN\u2010induced muscle atrophy did not affect macrophage and MDSC populations. In contrast, the percentage of cytotoxic T\u2010lymphocyte\u2010associated antigen (CTLA)\u20104\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells, programmed death (PD)\u20101\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells, regulatory T\u2010cells, and the CTLA\u20104\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T\u2010cells was statistically significantly higher in DN\u2010CLP mice than in sham\u2010CLP mice. Skeletal muscle atrophy before sepsis triggers excessive T\u00a0cell immunosuppression, which may contribute to the exacerbation of sepsis under skeletal muscle atrophy.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.14999","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T01:06:03Z","timestamp":1723165563000},"page":"2581-2591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["T\u2010cell immunosuppression in sepsis is augmented by sciatic denervation\u2010induced skeletal muscle atrophy"],"prefix":"10.1002","volume":"598","author":[{"given":"Sumika","family":"Osa","sequence":"first","affiliation":[{"name":"Division of Pharmacodynamics, Faculty of Pharmacy Keio University  Tokyo 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