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Mechanisms underlying HF remain incompletely understood. Splicing factors (SF), which control pre\u2010mRNA alternative splicing, regulate cardiac structure and function. This study investigated regulation of the splicing factor heterogeneous nuclear ribonucleoprotein\u2010L (hnRNPL) in the failing heart. hnRNPL protein increased in left ventricular tissue from mice with transaortic constriction\u2010induced HF and from HF patients. In left ventricular tissue, hnRNPL was detected predominantly in nuclei. Knockdown of the hnRNPL homolog Smooth in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    induced cardiomyopathy. Computational analysis of predicted mouse and human hnRNPL binding sites suggested hnRNPL\u2010mediated alternative splicing of tropomyosin, which was confirmed in C2C12 myoblasts. These findings identify hnRNPL as a sensor of cardiac dysfunction and suggest that disturbances of hnRNPL affect alternative splicing in HF.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.15020","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T23:13:38Z","timestamp":1726787618000},"page":"2670-2682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The splicing factor\n                    <scp>hnRNPL<\/scp>\n                    demonstrates conserved myocardial regulation across species and is altered in heart failure"],"prefix":"10.1002","volume":"598","author":[{"given":"Isabelle","family":"Draper","sequence":"first","affiliation":[{"name":"Molecular Cardiology Research Institute Tufts Medical Center  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Huang","sequence":"additional","affiliation":[{"name":"Molecular 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