{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:29:52Z","timestamp":1790875792001,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100003896","name":"Henry M. Jackson Foundation","doi-asserted-by":"publisher","award":["HU0001\u201021\u20102\u2010065"],"award-info":[{"award-number":["HU0001\u201021\u20102\u2010065"]}],"id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG005134"],"award-info":[{"award-number":["AG005134"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by accumulation of \u03b1\u2010synuclein cross\u2010\u03b2 amyloid filaments in the brain. Previous structural studies of these filaments by cryo\u2010electron microscopy (cryo\u2010EM) revealed three discrete folds distinct from \u03b1\u2010synuclein filaments associated with other neurodegenerative diseases. Here, we use cryo\u2010EM to identify a novel, low\u2010populated MSA filament subtype (designated Type I\n                    <jats:sub>2<\/jats:sub>\n                    ) in addition to a predominant class comprising MSA Type II\n                    <jats:sub>2<\/jats:sub>\n                    filaments. The 3.3\u2010\u00c5 resolution structure of the Type I\n                    <jats:sub>2<\/jats:sub>\n                    filament reveals a fold consisting of two asymmetric protofilaments, one of which adopts a novel structure that is chimeric between two previously reported protofilaments. These results further define MSA\u2010specific folds of \u03b1\u2010synuclein filaments and have implications for designing MSA diagnostics and therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.15048","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:49:25Z","timestamp":1731030565000},"page":"33-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Cryo\u2010\n                    <scp>EM<\/scp>\n                    structure of a novel \u03b1\u2010synuclein filament subtype from multiple system atrophy"],"prefix":"10.1002","volume":"599","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-550X","authenticated-orcid":false,"given":"Nicholas L.","family":"Yan","sequence":"first","affiliation":[{"name":"Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco  CA 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USA"},{"name":"Department of Pathology University of California San Francisco  CA USA"},{"name":"Department of Pathology Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-9389","authenticated-orcid":false,"given":"Daniel R.","family":"Southworth","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco  CA USA"},{"name":"Department of Biochemistry and Biophysics University of California San Francisco  CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-4056","authenticated-orcid":false,"given":"Nick A.","family":"Paras","sequence":"additional","affiliation":[{"name":"Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California San Francisco  CA USA"},{"name":"Department of Neurology Weill 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