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Genome databases suggest the expression of several spliced variants of subunits which may alter Pol\u03b4 function. Here, we analyzed the protein\u2010encoding variants of the Pol\u03b4 subunit p12 and their association with cancer. p12 isoform\u20102 (p12*) encodes a 79 aa protein with a C\u2010terminal tail distinct from the previously characterized p12. Like p12, p12* dimerizes and interacts with p125 and p50 subunits and is thus an integral component of Pol\u03b4. Further, we observed dysregulated p12* expression in low\u2010grade glioma, renal, thyroid, and pancreatic carcinomas. This study identifies a previously unrecognized Pol\u03b4 complex and highlights a possible regulatory role of p12 variants in cellular phenotypes.<\/jats:p>","DOI":"10.1002\/1873-3468.15070","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T14:24:00Z","timestamp":1733235840000},"page":"3087-3104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["p12 isoform\u20102 is a regulatory subunit of human\n                    <scp>DNA<\/scp>\n                    polymerase delta and is dysregulated in various cancers"],"prefix":"10.1002","volume":"598","author":[{"given":"Jugal Kishor","family":"Sahu","sequence":"first","affiliation":[{"name":"Laboratory of Genomic Instability and Diseases, Department of Infectious Disease Biology Institute of Life Sciences  Bhubaneswar India"},{"name":"Regional Center of Biotechnology  Faridabad 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