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The first stages of these diseases are reversible and the immune system, together with metabolic factors (obesity, insulin resistance, Western diet, etc.), can influence the disease trajectory leading to progression or regression. Dendritic cells are professional antigen\u2010presenting cells that constantly sense environmental stimuli and orchestrate immune responses. Herein, we discuss the existing literature on the heterogeneity of dendritic cell lineages, states, and functions, to provide a comprehensive overview of how liver dendritic cells influence the onset and evolution of MASLD.<\/jats:p>","DOI":"10.1002\/1873-3468.15072","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:59:37Z","timestamp":1734055177000},"page":"1971-1981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The immunological interface: dendritic cells as key regulators in metabolic dysfunction\u2010associated steatotic liver disease"],"prefix":"10.1002","volume":"599","author":[{"given":"Camilla","family":"Klaimi","sequence":"first","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011\u2010EGID  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9271-841X","authenticated-orcid":false,"given":"WanTing","family":"Kong","sequence":"additional","affiliation":[{"name":"Gustave Roussy, INSERM U1015  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-2888","authenticated-orcid":false,"given":"Camille","family":"Bl\u00e9riot","sequence":"additional","affiliation":[{"name":"Gustave Roussy, CNRS UMR9018, Metabolic and Systemic Aspects of Oncogenesis for New Therapeutic Approaches, Universit\u00e9 Paris\u2010Saclay  Villejuif France"},{"name":"Institut Necker Enfants Malades, CNRS, INSERM, Universit\u00e9 Paris Cit\u00e9  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel T.","family":"Haas","sequence":"additional","affiliation":[{"name":"Univ. 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