{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:27Z","timestamp":1792790427622,"version":"4.5.0"},"reference-count":212,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["MATTOSC24IO"],"award-info":[{"award-number":["MATTOSC24IO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["27060"],"award-info":[{"award-number":["27060"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>The arachidonic acid (AA) pathway promotes tumor progression by modulating the complex interactions between cancer and immune cells within the microenvironment. In this Review, we summarize the knowledge acquired thus far concerning the intricate mechanisms through which eicosanoids either promote or suppress the antitumor immune response. In addition, we will discuss the impact of eicosanoids on immune cells and how they affect responsiveness to immunotherapy, as well as potential strategies for manipulating the AA pathway to improve anticancer immunotherapy. Understanding the molecular pathways and mechanisms underlying the role played by AA and its metabolites in tumor progression may contribute to the development of more effective anticancer immunotherapies.<\/jats:p>","DOI":"10.1002\/1873-3468.70013","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T09:14:50Z","timestamp":1740042890000},"page":"927-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Immunoregulatory mechanisms of the arachidonic acid pathway in cancer"],"prefix":"10.1002","volume":"599","author":[{"given":"Maria","family":"Tredicine","sequence":"first","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"},{"name":"Center for Advanced Studies and Technology University of Chieti\u2010Pescara  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mucci","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"},{"name":"Center for Advanced Studies and Technology University of Chieti\u2010Pescara  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Recchiuti","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"},{"name":"Center for Advanced Studies and Technology University of Chieti\u2010Pescara  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2149-2855","authenticated-orcid":false,"given":"Domenico","family":"Mattoscio","sequence":"additional","affiliation":[{"name":"Department of Medical, Oral and Biotechnological Sciences University of Chieti\u2010Pescara  Italy"},{"name":"Center for Advanced Studies and Technology University of Chieti\u2010Pescara  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.1075.198"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612253152606"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0209"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3611"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2809"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.03.083"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37590-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.12.037"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18122661"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6835"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1381894"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.595498"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.10.027"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3859"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00443-w"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140244"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/89759"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00430.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1517642113"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.54.3.536"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.11.011"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800094-JLR200"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.41.1.661"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600038200"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2007.06.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1219160"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200246d"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711281105"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200206000-00007"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00021.2011"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.047100"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16009"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202100367"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S241893"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2875"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2217-1"},{"key":"e_1_2_9_43_1","first-page":"5261","article-title":"Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium\u2010induced colitis and carcinogenesis in mice","volume":"33","author":"Zhang W","year":"2013","journal-title":"Anticancer Res"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9315-y"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1925"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01713.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2020.02.014"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10269"},{"key":"e_1_2_9_49_1","first-page":"229","volume-title":"Advances in Pharmacology","author":"Pascale JV","year":"2023"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1521-8"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.123.001463"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.130336"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.174805"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4173"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.DMPK-11-RG-017"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.198515"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200110000-00006"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605428"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00278"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00702-z"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.637504"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-015-0260-7"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13331"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-018-9734-0"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-2627"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.123.000901"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2021.26.4.304"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-365825"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411221200"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl053"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802358"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-4245"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9297-9"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14624"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113418"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1556-0864(15)30350-6"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246154"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103235"},{"key":"e_1_2_9_79_1","first-page":"559","article-title":"Aspirin, ibuprofen, and other non\u2010steroidal anti\u2010inflammatory drugs in cancer prevention: a critical review of non\u2010selective COX\u20102 blockade (review)","volume":"13","author":"Harris RE","year":"2005","journal-title":"Oncol Rep"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.083"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02506-5"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2016.10.004"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0053rev"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161205774370753"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0150com"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20662"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020236"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2014.85"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001271"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154968"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-024-03016-1"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000037"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-006-9021-8"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.03.005"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1595-y"},{"key":"e_1_2_9_96_1","first-page":"617","volume-title":"Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury","author":"T\u00edm\u00e1r J","year":"1999"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115252"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115866"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-018-9738-9"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126473"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-1873"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6815727"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0655-5"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0173"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2019.106341"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.32456"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.15761\/ICST.1000337"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-21-0414"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30424"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97943"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2021.04.007"},{"key":"e_1_2_9_113_1","first-page":"1163","article-title":"Neutrophils in cancer: dual roles through intercellular interactions","volume":"43","author":"Yu X","year":"2024","journal-title":"Oncogene"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02552-z"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm934"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1177604"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8625"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1118-2"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4174"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8064"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.02.009"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02715-6"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.217"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.06.001"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.618501"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100889"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182542752"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202012798"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.05.011"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.154971"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600170"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28076"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06685-2"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612920114"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1027"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00719"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1261"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-024-00859-1"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.004"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.09.007"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0511-y"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0210-z"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.05.011"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.06.006"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3507"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16492"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1060"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5808962"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2255"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-383240"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73530"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06945-1"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.034"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.020"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350635"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0180-5"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01859"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/389849"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/341746a0"},{"key":"e_1_2_9_161_1","first-page":"1","article-title":"T\u00a0cells in health and disease","volume":"8","author":"Sun L","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/333180a0"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-023-00588-x"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0306-5"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00872-y"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-4029"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3469"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07254-x"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07352-w"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501648"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.09.005"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300967"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502376"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110914"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.07.022"},{"key":"e_1_2_9_176_1","article-title":"EP4 antagonism by E7046 diminishes myeloid immunosuppression and synergizes with Treg\u2010reducing IL\u20102\u2010diphtheria toxin fusion protein in restoring anti\u2010tumor immunity","volume":"6","author":"Albu DI","year":"2017","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.04.030"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00466-1"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050449"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12939"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201920"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0400"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.137"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110350"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201024\u20101611"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai7911"},{"key":"e_1_2_9_188_1","article-title":"Hydrogel dual delivered celecoxib and anti\u2010PD\u20101 synergistically improve antitumor immunity","volume":"5","author":"Li Y","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1815"},{"key":"e_1_2_9_190_1","article-title":"Does the combined use of aspirin and immunotherapy result in better outcomes in non\u2010small cell lung cancer than immunotherapy alone?","volume":"14","author":"Aiad M","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1259628"},{"key":"e_1_2_9_192_1","article-title":"Combination of EP4 antagonist MF\u2010766 and anti\u2010PD\u20101 promotes anti\u2010tumor efficacy by modulating both lymphocytes and myeloid cells","volume":"10","author":"Wang Y","year":"2021","journal-title":"Onco Targets Ther"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2023.101164"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7133726"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000222"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0561-4"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0413-z"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2385"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14034"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602023113"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29606-9"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.165356"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314085121"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(03)00073-5"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104857"},{"key":"e_1_2_9_206_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-021-01174-7"},{"key":"e_1_2_9_207_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2018.51.8.127"},{"key":"e_1_2_9_208_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2011.43.3.014"},{"key":"e_1_2_9_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.12.006"},{"key":"e_1_2_9_210_1","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2023.2290031"},{"key":"e_1_2_9_211_1","first-page":"3232","article-title":"Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells","volume":"8","author":"Tong W\u2010G","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_212_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.782584"},{"key":"e_1_2_9_213_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-01937-3"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T11:44:44Z","timestamp":1744631084000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.70013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,20]]},"references-count":212,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/1873-3468.70013"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.70013","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,20]]},"assertion":[{"value":"2024-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}