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They contain specialized mitochondria in which hypoxia induces the accumulation of NADH and H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    that modulate membrane ion channel activity. We investigated whether hypoxia induces reverse electron transport (RET) at mitochondrial complex I (MCI). We studied glomus cells from mice with a mutation in ND6, a core protein of MCI, which maintain normal MCI NADH dehydrogenase activity but cannot catalyze RET. The ND6 mutation increases the propensity of MCI to deactivate, and glomus cells with deactivated MCI are insensitive to acute hypoxia. These findings further indicate that MCI function is necessary for glomus cell responsiveness to hypoxia, although MCI RET does not seem to be required for this process.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70017","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:20:22Z","timestamp":1740115222000},"page":"1122-1134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Acute oxygen sensing by arterial chemoreceptors with a mutant mitochondrial complex I\n                    <scp>ND6<\/scp>\n                    subunit lacking reverse electron transport"],"prefix":"10.1002","volume":"599","author":[{"given":"Mar\u00eda","family":"Torres\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Institute of Biomedicine of Seville (IBiS) University Hospital \u2018Virgen del Roc\u00edo\u2019\/CSIC\/University of Seville  Spain"},{"name":"Department of Medical 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