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REP1 is essential for the post\u2010translational prenylation of the key players in intracellular membrane trafficking, the Rab GTPases. In this study, we aimed to analyze the mechanisms of retinal degeneration caused by Rep deficiency using the\n                      <jats:italic>Drosophila<\/jats:italic>\n                      retina as a model system. Rab GTPases lost their membrane association ability and diffused into the cytoplasm, and the accumulation of unprenylated Rab6 and Rab7 was observed in Rep\u2010deficient photoreceptors. Notably, Rep\u2010deficient photoreceptors underwent progressive cell death\n                      <jats:italic>via<\/jats:italic>\n                      cell swelling and rupture rather than apoptosis. These findings provide new insight to seek a therapeutic approach to CHM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                        <jats:caption>\n                          <jats:title>Impact statement<\/jats:title>\n                        <\/jats:caption>\n                        <jats:p>\n                          Choroideremia is an inherited retinal degeneration caused by a deficiency of Rab escort protein 1 (Rep\u20101). We used the\n                          <jats:italic>Drosophila<\/jats:italic>\n                          retina as a model to study the mechanism of retinal degeneration in Rep\u2010deficiency and found that Rep\u2010deficient photoreceptors undergo progressive cell death\n                          <jats:italic>via<\/jats:italic>\n                          cell swelling and rupture rather than apoptosis.\n                        <\/jats:p>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1873-3468.70056","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:39:23Z","timestamp":1746499163000},"page":"2598-2611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lytic photoreceptor cell death caused by Rab escort protein deficiency in\n                    <i>Drosophila<\/i>"],"prefix":"10.1002","volume":"599","author":[{"given":"Shogo","family":"Sasaki","sequence":"first","affiliation":[{"name":"Program of Life and Environmental Science, Graduate School of Integrated Science for Life Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Satoh","sequence":"additional","affiliation":[{"name":"Program of Life and Environmental Science, Graduate School of Integrated Science for Life Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takunori","family":"Satoh","sequence":"additional","affiliation":[{"name":"Program of Life and Environmental Science, Graduate School of Integrated Science for Life Hiroshima University  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-6642","authenticated-orcid":false,"given":"Akiko K.","family":"Satoh","sequence":"additional","affiliation":[{"name":"Program 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