{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:55:54Z","timestamp":1772117754475,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["AAPG\u20102021\u2010DR07\u2010050321"],"award-info":[{"award-number":["AAPG\u20102021\u2010DR07\u2010050321"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    <jats:italic>Brucella abortus<\/jats:italic>\n                    is the cause of one of the most prevalent zoonoses worldwide. We have recently discovered two translocated effectors, NyxA and NyxB, that contribute to the late stages of the infectious cycle. Although their structure was solved, the importance of their interactions and dimeric states remains unknown. We found that NyxA and NyxB directly interact and that their dimerization is essential for their function during infection. We show that monomeric forms of the Nyx effectors still interact with their host cellular target, the deSUMOylase sentrin\u2010specific protease 3 (SENP3) but are less able than the dimers to delocalize SENP3 from the nucleoli. This study provides new insights into the intra\u2010 and inter\u2010effector molecular interactions during\n                    <jats:italic>Brucella<\/jats:italic>\n                    pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70069","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T03:15:31Z","timestamp":1747797331000},"page":"1852-1863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Brucella<\/i>\n                    <scp>NyxA<\/scp>\n                    and\n                    <scp>NyxB<\/scp>\n                    dimerization enhances effector function during infection"],"prefix":"10.1002","volume":"599","author":[{"given":"Lison","family":"Cancade\u2010Veyre","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Microbiology and Structural Biochemistry, Centre National de la Recherche Scientifique UMR5086 Universit\u00e9 de Lyon  France"},{"name":"Department of Pathobiological Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison  WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Louche","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology and Structural Biochemistry, Centre National de la Recherche Scientifique UMR5086 Universit\u00e9 de Lyon  France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine C. 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