{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:51:52Z","timestamp":1772117512323,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    The oncogene\n                    <jats:italic>hbz<\/jats:italic>\n                    in human T\u2010cell leukemia virus type 1 (HTLV\u20101) is encoded on the antisense strand, generating spliced and unspliced transcripts. We investigated splicing regulation in the context of cellular splice donors and the\n                    <jats:italic>hbz<\/jats:italic>\n                    splice acceptor when integrated within the host chromosomal DNA. In ATL cell line ED, the HTLV\u20101 provirus integrated into the 10th intron of the gene\n                    <jats:italic>ift81<\/jats:italic>\n                    , aligning transcriptionally with\n                    <jats:italic>ift81<\/jats:italic>\n                    . Both genes were actively transcribed, yielding\n                    <jats:italic>ift81\u2013hbz<\/jats:italic>\n                    chimeric mRNA but not\n                    <jats:italic>hbz\u2013ift81<\/jats:italic>\n                    . Splicing efficiency from the 10th exon of\n                    <jats:italic>ift81<\/jats:italic>\n                    to the 2nd exon of\n                    <jats:italic>hbz<\/jats:italic>\n                    was 24.2% at most, suggesting reduced function of\n                    <jats:italic>hbz<\/jats:italic>\n                    splice signals on\n                    <jats:italic>ift81<\/jats:italic>\n                    \u2010driven transcripts. This stochastic regulation may minimize disruption of cellular gene expression by proviral integration, potentially promoting survival of HTLV\u20101\u2010infected cells and contributing to HTLV\u20101 pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70104","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:43:07Z","timestamp":1751416987000},"page":"2620-2628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intron\u2010oriented\n                    <scp>HTLV<\/scp>\n                    \u20101 integration in an adult T\u2010cell leukemia\/lymphoma cell line sustains expression of intact\n                    <i>ift81<\/i>\n                    <scp>mRNA<\/scp>"],"prefix":"10.1002","volume":"599","author":[{"given":"Mayuko","family":"Yagi","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Microbiology and Infection Control Osaka Medical and Pharmaceutical University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Hirosawa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Microbiology and Infection Control Osaka Medical and Pharmaceutical University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusaku","family":"Sagisaka","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Microbiology and Infection Control Osaka Medical and Pharmaceutical University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minami","family":"Hama","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Microbiology and Infection Control Osaka Medical and Pharmaceutical University  Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Laboratory Animal and Pathogen 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