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To investigate how\n                    <jats:italic>Kit<\/jats:italic>\n                    structural mutations associated with the porcine dominant white phenotype affect hematopoiesis, we utilized three distinct gene\u2010edited mouse models:\n                    <jats:italic>Kit<\/jats:italic>\n                    coding sequence (CDS) duplication (\n                    <jats:italic>Kit<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>dup<\/jats:italic>\n                      \/+\n                    <\/jats:sup>\n                    ),\n                    <jats:italic>Kit<\/jats:italic>\n                    exon 17 deletion (\n                    <jats:italic>Kit<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>D17<\/jats:italic>\n                      \/+\n                    <\/jats:sup>\n                    ), and a compound heterozygous model carrying both mutations (\n                    <jats:italic>Kit<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>dup\/D17<\/jats:italic>\n                    <\/jats:sup>\n                    ), along with wild\u2010type controls (\n                    <jats:italic>Kit<\/jats:italic>\n                    <jats:sup>+\/+<\/jats:sup>\n                    ). We observed that the\n                    <jats:italic>Kit<\/jats:italic>\n                    structural mutations significantly impaired erythropoiesis in bone marrow, resulting in hypoplastic macrocytic anemia and compensatory erythropoiesis in the spleen. Transcriptomic analyses revealed that these structural\n                    <jats:italic>Kit<\/jats:italic>\n                    mutations attenuate PI3K and MAPK signaling activation and downregulate genes essential for erythroid differentiation. Our findings provide novel mechanistic insights into how\n                    <jats:italic>Kit<\/jats:italic>\n                    mutations contribute to hematopoietic dysfunction.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70144","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:20:01Z","timestamp":1755602401000},"page":"3301-3317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Kit<\/i>\n                    structural mutations associated with the porcine dominant white phenotype impair hematopoiesis in mice"],"prefix":"10.1002","volume":"599","author":[{"given":"Chong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010Sen University  Guangzhou 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