{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:50:05Z","timestamp":1792227005203,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI 22K08663"],"award-info":[{"award-number":["KAKENHI 22K08663"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    The protective effects of imeglimin, a recently approved antidiabetic agent, against liver fibrosis have not been previously evaluated. In this study, we demonstrated that 8\u2010week administration of imeglimin attenuated immune cell infiltration and reduced collagen deposition, improving fibrosis stage in a thioacetamide\u2010induced murine model. Further analyses focusing on hepatic stellate cells (HSCs), the primary effector cells in fibrogenesis, revealed decreased expression of \u03b1\u2010smooth muscle actin and desmin, markers of HSC activation. Mechanistically, a clinically relevant low concentration (10\u2009\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ) of imeglimin reduced intracellular vesicular ATP accumulation and subsequently suppressed ATP release from HSCs\n                    <jats:italic>in vitro<\/jats:italic>\n                    . These findings suggest that imeglimin may exert anti\u2010inflammatory and antifibrotic effects by inhibiting vesicular ATP release and ATP\u2010mediated purinergic signaling.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                      <jats:caption>\n                        <jats:title>Impact statement<\/jats:title>\n                      <\/jats:caption>\n                      <jats:p>At clinically relevant doses, imeglimin inhibits vesicular ATP release from hepatic stellate cells, reducing inflammatory infiltration and fibrotic collagen accumulation. These findings support its evaluation as a combined metabolic and antifibrotic therapy for MASLD and other chronic liver conditions.<\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70166","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T08:45:07Z","timestamp":1757925907000},"page":"3524-3536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Imeglimin attenuates liver fibrosis by inhibiting vesicular\n                    <scp>ATP<\/scp>\n                    release from hepatic stellate cells"],"prefix":"10.1002","volume":"599","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7706-1034","authenticated-orcid":false,"given":"Seiji","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Kurume University School of Medicine  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