{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T07:56:29Z","timestamp":1774857389748,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Poly(ADP\u2010ribose) polymerase\u20101 (PARP\u20101) is a multidomain enzyme essential for the DNA damage response; its inhibition can lead to cancer cell death. Recruitment of PARP\u20101 to sites of genomic damage is mediated by its zinc finger domains. In this study, we investigated the inhibition of PARP\u20101's DNA\u2010dependent activation by three Au(I)\u2010based drugs, presumable zinc\u2010ejectors. We found that aurothioglucose and sodium aurothiomalate selectively inhibited PARP\u20101's DNA\u2010dependent activity, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the nanomolar range, while preserving its DNA\u2010independent activity. Furthermore, in a BRCA\u2010mutated cell line, both compounds effectively suppressed DNA replication, with half\u2010maximal effective concentrations (EC\n                    <jats:sub>50<\/jats:sub>\n                    ) also in the nanomolar range. These findings highlight the potential of selective, zinc finger\u2013targeting PARP\u20101 inhibitors as promising candidates for anticancer drug testing.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                      <jats:caption>\n                        <jats:title>Impact statement<\/jats:title>\n                      <\/jats:caption>\n                      <jats:p>The need to preserve basal poly(ADP\u2010ribose) polymerase\u20101 (PARP\u20101) activity in healthy cells, along with the search for alternative anticancer therapies in cases of drug resistance, led to the discovery of selective and potent zinc finger\u2013targeting inhibitors of PARP\u20101. This finding opens new opportunities for anticancer drug development.<\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70224","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:05:32Z","timestamp":1763035532000},"page":"3618-3628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The zinc finger domains of\n                    <scp>PARP<\/scp>\n                    \u20101 are selectively and potently inhibited by the Au(I)\u2010based drugs sodium aurothiomalate and aurothioglucose"],"prefix":"10.1002","volume":"599","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9250-7804","authenticated-orcid":false,"given":"Uliana","family":"Bashtanova","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry University of Cambridge  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda 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