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Reduced hydrogen sulphide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) levels and dysregulation of the H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010producing enzyme 3\u2010mercaptopyruvate sulfurtransferase (3\u2010MST) are linked to this dysfunction. Dihydrolipoic acid (DHLA), formed from alpha\u2010lipoic acid in mitochondria, has been proposed to enhance H\n                    <jats:sub>2<\/jats:sub>\n                    S release from 3\u2010MST; however, this has not been empirically tested in diabetes. Using a cell culture model, this study demonstrates that DHLA supplementation enhances H\n                    <jats:sub>2<\/jats:sub>\n                    S production via 3\u2010MST and improves endothelial function under high glucose conditions. Our results provide foundational knowledge and indicate that targeting the 3\u2010MST\/H\n                    <jats:sub>2<\/jats:sub>\n                    S pathway via DHLA supplementation may have therapeutic potential to reduce or slow the onset and progression of diabetic microvascular complications.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70239","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:15:35Z","timestamp":1764069335000},"page":"3642-3655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dihydrolipoic acid improves diabetic endothelial cell function via the\n                    <scp>\n                      H\n                      <sub>2<\/sub>\n                      S\n                    <\/scp>\n                    \u2010producing enzyme 3\u2010mercaptopyruvate 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