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By comparing direct mutant p53 binding between 26 ETS proteins, we found that all bound mutant p53, but relative binding differed significantly. The ETS DNA binding domain provided a common interaction interface, but strong binding required an alternate interaction domain highlighted by a PXXPP motif found in five ETS proteins. Genome\u2010wide mapping found that the ETS protein ERG mediated some mutant p53 DNA binding in prostate cancer cells. Lastly, ETS proteins that interact strongly with mutant p53 tended to be upregulated in p53 mutant ovarian cancer. These results identify multiple ETS family members that could mediate mutant p53 function in cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                        <jats:caption>\n                          <jats:title>Impact statement<\/jats:title>\n                        <\/jats:caption>\n                        <jats:p>The mechanisms behind gain\u2010of\u2010function mutant p53 remain unclear. Here we identify distinct domains and a novel motif that can mediate binding of mutant p53 to multiple different ETS family transcription factors.<\/jats:p>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1873-3468.70260","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:14:55Z","timestamp":1767176095000},"page":"1248-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple\n                    <scp>ETS<\/scp>\n                    family transcription factors bind mutant p53\n                    <i>via<\/i>\n                    distinct interaction regions"],"prefix":"10.1002","volume":"600","author":[{"given":"Stephanie A.","family":"Metcalf","sequence":"first","affiliation":[{"name":"Medical Sciences Indiana University School of Medicine  Bloomington IN 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