{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:29:33Z","timestamp":1776104973986,"version":"3.50.1"},"reference-count":78,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    The t(10;11)(p13;q14\u201021)\n                    <jats:italic>PICALM::MLLT10<\/jats:italic>\n                    chromosomal translocation results in the production of the CALM\u2010AF10 fusion oncoprotein and is a driver mutation in both acute myeloid and T\u2010lymphoblastic leukemia.\n                    <jats:italic>PICALM::MLLT10<\/jats:italic>\n                    translocated leukemia is primarily an epigenetically driven disease. Global hypomethylation results in genomic instability, while focal H3K79 hypermethylation at target genes induces cell proliferation and blocks differentiation. Nucleocytoplasmic shuttling of CALM\u2010AF10 and its protein partners and impaired endocytosis at the plasma membrane further influence the leukemic phenotype. Leukemias characterized by\n                    <jats:italic>PICALM::MLLT10<\/jats:italic>\n                    have historically been recognized to portend a poor prognosis; however, insights from larger patient cohorts provide refinement to the prognostic relevance of this chromosomal translocation, highlighting chemotherapy resistance in this leukemic subtype. In addition, a deeper biological understanding of the disease hints at potential therapeutic targets. This approach is demonstrated in the recent promising results achieved utilizing venetoclax, a BCL2 inhibitor, in patients with\n                    <jats:italic>PICALM::MLLT10<\/jats:italic>\n                    acute leukemia. Herein, we provide updates on the pathophysiology, clinical presentation, prognosis, and treatment of\n                    <jats:italic>PICALM::MLLT10<\/jats:italic>\n                    acute leukemia.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70279","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:48:18Z","timestamp":1768391298000},"page":"1028-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>PICALM<\/scp>\n                    ::\n                    <scp>MLLT10<\/scp>\n                    translocated leukemia"],"prefix":"10.1002","volume":"600","author":[{"given":"John M.","family":"Cullen","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Vermont Larner College of Medicine  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia C.","family":"Nakatsugawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Vermont Larner College of Medicine  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Barton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Vermont Larner College of Medicine  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Haines","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Vermont Larner College of Medicine  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Vermont Larner College of Medicine  Burlington USA"},{"name":"University of Vermont Cancer Center  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet L.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Vermont Larner College of Medicine  Burlington USA"},{"name":"University of Vermont Cancer Center  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Wechsler","sequence":"additional","affiliation":[{"name":"Aflac Cancer &amp; Blood Disorders Center, Children's Healthcare of Atlanta  USA"},{"name":"Department of Pediatrics Emory University School of Medicine  Atlanta USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-2242","authenticated-orcid":false,"given":"Jessica L.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Vermont Larner College of Medicine  Burlington USA"},{"name":"Department of Biochemistry University of Vermont Larner College of Medicine  Burlington USA"},{"name":"University of Vermont Cancer Center  Burlington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405074"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11243994"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091242"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.1999.31"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes4030388"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162050"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.8.2687"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044252"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129776"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2014.08.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.119537"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.03.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304346200"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-435792"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.221"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33465"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210945"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2106148118"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1898410"},{"key":"e_1_2_11_21_1","first-page":"2823","article-title":"The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target","volume":"5","author":"Wong M","year":"2015","journal-title":"Am J Cancer Res"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000539"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-021-00406-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.08.019"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24418-9"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3766"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.153"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904672116"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2020.06.002"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4804"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3749"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2008.08.001"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0998-3"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1464"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12347"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.251"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.7.1511"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80371-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232036"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09540"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-209395"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216606"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00114-4"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00901-6"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02076-07"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.154"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/150.2.613"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8010011"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-018-0601-1"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.28104"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000190"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.917125"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.115"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2016.03.015"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.06.010"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334359"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.009"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.020"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403891"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401578"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.2.617-628.2004"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3906\/biy-2006-25"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.04.003"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01572"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.327"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02194-x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031854"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.09.009"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2024.07.003"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.149"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2913"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19067"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2024.2423324"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.922"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280433"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.5892"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30791"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-661702"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.2780.2780"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.70279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T17:15:52Z","timestamp":1776100552000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.70279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":78,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/1873-3468.70279"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.70279","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}