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Uptake of oxidized LDL (oxLDL) by macrophages occurs via receptor\u2010mediated endocytosis through various scavenger receptors. Although resting macrophages internalize modified LDL mainly via SR\u2010A and CD36 receptors, evidence suggests an important role for LOX\u20101 in the transformation of macrophages into foam cells, despite the low level of LOX\u20101 on the surface membrane of resting macrophages. Here we describe novel positive feedback loops involving anaphylatoxin C3a and its receptor, which lead to increased LOX\u20101 levels in macrophages and reveal the molecular mechanisms underlying these processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                        <jats:caption>\n                          <jats:title>Impact statement<\/jats:title>\n                        <\/jats:caption>\n                        <jats:p>Little is known about processes which control the transformation of macrophages into foam cells in atherosclerotic lesions. Here, we describe novel positive feedback loops associated with anaphylatoxin C3a and its receptor, which lead to escalation of oxLDL uptake by macrophages, and reveal the central role of the LOX\u20101 receptor in this process.<\/jats:p>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/1873-3468.70282","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T17:43:30Z","timestamp":1768844610000},"page":"669-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The\n                    <scp>LOX<\/scp>\n                    \u20101 scavenger receptor plays a central role in multiple positive feedback loops driving the escalation of ox\n                    <scp>LDL<\/scp>\n                    uptake by macrophages"],"prefix":"10.1002","volume":"600","author":[{"given":"Alexandra A.","family":"Dmitrieva","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Genetics and Fundamental Medicine Institute of Experimental Medicine  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Mogilenko","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genetics and Fundamental Medicine Institute of Experimental Medicine  Saint\u2010Petersburg Russia"},{"name":"Department of Embryology Saint\u2010Petersburg State University  Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina E.","family":"Larionova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Genetics and Fundamental Medicine Institute of Experimental Medicine  Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-4626","authenticated-orcid":false,"given":"Ekaterina 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