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Despite significant progress in understanding the general mechanisms of allergic sensitization, the development of oral tolerance remains a major challenge in advancing food allergy research and treatment. Additionally, each allergenic food source has a distinct immunological profile and tolerance trajectory, further complicating research efforts. Currently, oral allergen\u2010specific immunotherapy is the only treatment that can help build tolerance to certain food allergens over time\u2014although treatment outcomes vary. While B cells have been described and studied for their pathogenic role in food allergy, recent evidence suggests that they also modulate allergic responses through various effector and humoral functions. Notably, despite their low frequency, recent knowledge on the molecular and functional characteristics of food allergen\u2010specific memory B cells has revealed important functions during both disease progression and therapeutic intervention. This review summarizes the current knowledge of IgE\u2010mediated food allergy, highlighting the role of B cells, especially allergen\u2010specific ones, in both disease and immune tolerance.<\/jats:p>","DOI":"10.1002\/1873-3468.70305","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:44:08Z","timestamp":1771566248000},"page":"1137-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of\n                    <scp>IgE<\/scp>\n                    \u2010mediated food allergy and the role of allergen\u2010specific B cells"],"prefix":"10.1002","volume":"600","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9993-9530","authenticated-orcid":false,"given":"Juan\u2010Felipe","family":"L\u00f3pez","sequence":"first","affiliation":[{"name":"Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich  Davos 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