{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:59:56Z","timestamp":1785448796296,"version":"3.56.0"},"reference-count":73,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Abnormal accumulation of misfolded proteins is a hallmark of neurodegenerative diseases. Amyloid aggregation of \u03b1\u2010synuclein (\u03b1\u2010Syn) and TAR DNA\u2010binding protein 43 (TDP\u201043) contributes to Parkinson's disease and frontotemporal dementia, respectively. The heterotypic aggregates are increasingly recognized as highly cytotoxic. Given the frequent co\u2010occurrence of \u03b1\u2010Syn, TDP\u201043, and tau pathologies, we examined whether the first prion\u2010like domain (PRD1) of CPEB3 modulates \u03b1\u2010Syn and TDP\u201043 aggregation. Nuclear magnetic resonance (NMR) relaxation experiments revealed a direct interaction between PRD1 and the amyloid core of \u03b1\u2010Syn, suppressing its aggregation, while phase separation assays showed delayed liquid\u2013liquid phase separation (LLPS) \u2010mediated \u03b1\u2010Syn aggregation. In contrast, no interaction was detected with the C\u2010terminal domain of TDP\u201043 (TDP\u201043\n                    <jats:sub>CTD<\/jats:sub>\n                    ), indicating selective inhibition of \u03b1\u2010Syn aggregation by PRD1.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70308","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:42:55Z","timestamp":1773009775000},"page":"2012-2027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CPEB3<\/scp>\n                    selectively inhibits \u03b1\u2010synuclein aggregation without modulating\n                    <scp>TDP<\/scp>\n                    \u201043 pathology"],"prefix":"10.1002","volume":"600","author":[{"given":"Ann Teres","family":"Babu","sequence":"first","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM)  Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mufeeda Farhana","family":"A","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM)  Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha Varthini","family":"Periasamy","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM)  Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-1860","authenticated-orcid":false,"given":"Vinesh","family":"Vijayan","sequence":"additional","affiliation":[{"name":"School of Chemistry Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM)  Thiruvananthapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108050"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-014-0082-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1157-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1657108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124514"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/648740"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.033"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-024-00407-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2019.03.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4269"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3406"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12125"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008919200"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36402"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02088-w"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-020-0465-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00025"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00301"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002338"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7183"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900688106"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.09.048"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102459"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.007"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3887"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3549"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww224"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2020.04.088"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001831"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-322983"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02077-x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14602"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.2870505"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.017"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00128-8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021774"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.060"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.042"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017452118"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05672-9"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.194"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32687-1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201702800"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074969"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012171118"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1808-9"},{"key":"e_1_2_10_50_1","first-page":"1","article-title":"Keeping \u03b1\u2010Synuclein at bay: a more active role of molecular chaperones in preventing mitochondrial interactions and transition to pathological states?","volume":"10","author":"Aspholm EE","year":"2020","journal-title":"Life (Basel)"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0384-x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407146102"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506109102"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700368200"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470034590.emrstm1363"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2018.01.019"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.1c03794"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b02424"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.764886"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01418-5"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109541200"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.04.016"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1906124116"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0322-y"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308279"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.699"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315346111"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102926"},{"key":"e_1_2_10_69_1","article-title":"Studying protein aggregation in the context of liquid\u2010liquid phase separation using fluorescence and atomic force microscopy, fluorescence and turbidity assays, and FRAP","volume":"10","author":"Babinchak WM","year":"2020","journal-title":"Bio Protoc"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11040548"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2016.07.007"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007222"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3920"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01791-8"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.70308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:22:48Z","timestamp":1785446568000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.70308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":73,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/1873-3468.70308"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.70308","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}