{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:29:45Z","timestamp":1776104985533,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770165"],"award-info":[{"award-number":["81770165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Dysregulation of the transcription factor MYB plays a critical role in leukemia pathogenesis, progression, and prognosis; however, the detailed regulatory mechanisms of MYB remain unclear. Recently, we identified an enhancer long noncoding RNA (lncRNA) MY34UE\u2010AS, which upregulates MYB expression. Here, we demonstrate that non\u2010POU\u2010domain\u2010containing octamer binding protein (NONO) binds to MY34UE\u2010AS through its RNA recognition motif 2 (RRM2) domain, thereby upregulating\n                    <jats:italic>MYB<\/jats:italic>\n                    expression and splicing. This interaction drives leukemia cell proliferation and migration. Our findings unveil a novel regulatory mechanism of MYB and propose the NONO\u2013MY34UE\u2010AS axis as a potential therapeutic target for leukemia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                      <jats:caption>\n                        <jats:title>Impact statement<\/jats:title>\n                      <\/jats:caption>\n                      <jats:p>Our study uncovers the NONO\u2013MY34UE\u2010AS\u2013MYB regulatory axis in leukemia, revealing a new layer of MYB control. This mechanistic insight advances understanding of oncogenic transcription factor dysregulation and highlights potential therapeutic targets, offering new directions for leukemia research.<\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70316","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:01:03Z","timestamp":1773208863000},"page":"1062-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>NONO<\/scp>\n                    promotes\n                    <scp>MYB<\/scp>\n                    expression and splicing by interacting with enhancer\n                    <scp>lncRNA MY34UE<\/scp>\n                    \u2010\n                    <scp>AS<\/scp>\n                    in human leukemia cells"],"prefix":"10.1002","volume":"600","author":[{"given":"Siyu","family":"Shen","sequence":"first","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  China"},{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  China"},{"name":"Marine Biomedical Science and Technology Innovation Platform of Lin\u2010gang Special Area  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  China"},{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  China"},{"name":"Marine Biomedical Science and Technology Innovation Platform of Lin\u2010gang Special Area  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  China"},{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  China"},{"name":"Marine Biomedical Science and Technology Innovation Platform of Lin\u2010gang Special Area  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University  China"},{"name":"National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean University  China"},{"name":"Marine Biomedical Science and Technology Innovation Platform of Lin\u2010gang Special 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