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Here, we used recombinant protein constructs and antibodies corresponding to\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    ring\u2010infected erythrocyte surface antigen\u20103 (PfRESA3) to identify it as a dense granule merozoite protein exported early to the inner erythrocyte membrane, where it associates with the cytoskeleton. Constructs lacking the J domain bound inside\u2010out vesicles, implicating PRESAN and DnaJ\u2010X in cytoskeletal interactions. Recombinant PfRESA3 constructs stimulated the ATPase activity of human HsHSPA8 and enhanced malate dehydrogenase (MDH) refolding. However, truncated PfRESA3 constructs did not significantly enhance MDH refolding by HsHSPA8. These findings suggest PfRESA3 modulates host HsHSPA8 to support cytoskeletal remodeling\/parasite protein folding early in infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:boxed-text content-type=\"box\" position=\"anchor\">\n                      <jats:caption>\n                        <jats:title>Impact statement<\/jats:title>\n                      <\/jats:caption>\n                      <jats:p>Our study uncovers a high\u2010stakes hijacking of the human erythrocyte by Plasmodium falciparum. By identifying PfRESA3 as a potential co\u2010chaperone that anchors to the host's cytoskeleton and recruits human chaperones, this study reveals a sophisticated survival strategy. It exposes a critical vulnerability in the parasite's early development inside the human erythrocyte.<\/jats:p>\n                    <\/jats:boxed-text>\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70340","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:41:53Z","timestamp":1776051713000},"page":"2744-2764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Plasmodium falciparum<\/i>\n                    ring\u2010infected erythrocyte surface antigen 3 (\n                    <scp>PfRESA3<\/scp>\n                    ) is a cytoskeleton\u2010interacting protein and potential co\u2010chaperone"],"prefix":"10.1002","volume":"600","author":[{"given":"Nipa Rani","family":"Mallick","sequence":"first","affiliation":[{"name":"School of Biotechnology Kalinga Institute of Industrial Technology (KIIT) Deemed to be University  Bhubaneswar Odisha 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