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Treating 3\u2009T3\u2010F442A pre\u2010adipocytes with conditioned medium (CM) from M1\u2010like RAW264.7 cells resulted in a significant upregulation of TG\u2010interacting factor 1 (Tgif1) expression. Using a Tgif1 promoter reporter assay, we showed that the tumor necrosis factor (TNF) transcriptionally upregulates Tgif1 promoter activity, consistent with increased mRNA and protein expression. We also demonstrated that Tgif1 contributes to the modulation of TNF\u2010driven\n                    <jats:italic>Il\u20106<\/jats:italic>\n                    and\n                    <jats:italic>Ccl2<\/jats:italic>\n                    cytokine mRNA expression in Tgif1\u2010knockout and Tgif1\u2010overexpressing 3\u2009T3\u2010F442A pre\u2010adipocytes. CM from Tgif1\u2010overexpressing cells showed a positive correlation between Tgif1 expression and PCa cell migration. We conclude that Tgif1 mediates TNF\u2010induced Ccl2 expression in pre\u2010adipocytes, thereby promoting PCa progression.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70357","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:29:21Z","timestamp":1779690561000},"page":"1885-1896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TG<\/scp>\n                    \u2010interacting factor 1 mediates\n                    <scp>TNF<\/scp>\n                    \u2010induced Ccl2 expression in adipocytes to promote prostate cancer progression"],"prefix":"10.1002","volume":"600","author":[{"given":"Kuan\u2010Hua","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery Chi Mei Medical Center  Tainan 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