{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:08:14Z","timestamp":1783930094520,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>\n                    Hyperglycaemia is an independent risk factor for pancreatic cancer (PC). Here, we show that both chronic and intermittent high glucose cause a robust upregulation of the novel lncRNA LINC00538 (\n                    <jats:italic>YIYA<\/jats:italic>\n                    ) in pancreatic ductal adenocarcinoma (PDAC) cells.\n                    <jats:italic>YIYA<\/jats:italic>\n                    enhances PDAC cell proliferation in both 2D and 3D culture systems, and its expression shows a positive correlation with poor patient survival. Importantly, knockdown of\n                    <jats:italic>YIYA<\/jats:italic>\n                    attenuates the proliferative effect. Mechanistically,\n                    <jats:italic>YIYA<\/jats:italic>\n                    drives the Warburg phenotype\u00a0in a KRAS\u2010dependent manner.\n                    <jats:italic>YIYA<\/jats:italic>\n                    physically interacts with KRAS and the glycolytic enzyme pyruvate kinase 2 (PKM2). Notably,\n                    <jats:italic>YIYA<\/jats:italic>\n                    stabilises KRAS by preventing its autophagy\u2010mediated degradation, thereby\u00a0sustaining\u00a0a proliferative state. This study identifies\n                    <jats:italic>YIYA<\/jats:italic>\n                    as a glucose\u2010responsive lncRNA that links KRAS signalling to metabolic reprogramming in PDAC.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70378","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:21:13Z","timestamp":1780914073000},"page":"1911-1930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>LncRNA<\/scp>\n                    <i>YIYA<\/i>\n                    drives pancreatic cancer proliferation under\u00a0high\u2010glucose conditions by reinforcing a\n                    <scp>RAS<\/scp>\n                    \u2013\n                    <scp>PKM2<\/scp>\n                    \u2010dependent Warburg phenotype"],"prefix":"10.1002","volume":"600","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7547-294X","authenticated-orcid":false,"given":"Nachiket Dattatray","family":"Garge","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Birla Institute of Technology and Science (BITS) Pilani  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Birla Institute of Technology and Science (BITS) Pilani  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Birla Institute of Technology and Science (BITS) Pilani  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-0613","authenticated-orcid":false,"given":"Rajdeep","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Birla Institute of Technology and Science (BITS) Pilani  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