{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:11:13Z","timestamp":1788372673023,"version":"build-2803163510"},"reference-count":156,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC CoG2022 LifeLongFit (European Commission)"],"award-info":[{"award-number":["ERC CoG2022 LifeLongFit (European Commission)"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007569","name":"Carl-Zeiss-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"abstract":"<jats:p>\n                    Proteostasis and the gut microbiota are two major determinants of host health and longevity. Proteostasis ensures proper protein folding and degradation thereby preventing the accumulation of unwanted proteins. Similarly, microbiota contribute to host metabolism, immunity, and protection from pathogens. However, as aging progresses, the proteostasis network declines, and the composition and functionality of gut microbiota are altered, often resulting in dysbiosis. While the impact of the microbiota on various aspects of host physiology is extensively studied, its specific influence on host protein quality control remains relatively underexplored. In this review, we provide an integrated overview of the relationship between microbiota and host proteostasis. Accumulating findings, particularly from\n                    <jats:italic>C. elegans<\/jats:italic>\n                    models, provide substantial support for the concept that microbiota\u2010derived factors (vitamins and RNA) can shape host proteostasis and influence aging\u2010related phenotypes. We discuss emerging evidence showing that microbial communities and their metabolites can either support or impair cellular proteostasis, highlighting their potential as prebiotics or dietary intervention candidates for promoting healthy aging. Understanding the intricate interplay between microbiota and proteostasis opens new avenues for designing microbiota\u2010based strategies for healthy aging.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70386","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:29:33Z","timestamp":1781688573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbiome\u2212host proteostasis crosstalk\u2014An emerging perspective on mechanisms and interventions toward healthy longevity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-7526","authenticated-orcid":false,"given":"Abhishek Anil","family":"Dubey","sequence":"first","affiliation":[{"name":"Leibniz Institute on Aging \u2013 Fritz Lipmann Institute (FLI)  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ermolaeva","sequence":"additional","affiliation":[{"name":"Leibniz Institute on Aging \u2013 Fritz Lipmann Institute (FLI)  Jena Germany"},{"name":"Cluster of Excellence Balance of the Microverse Friedrich Schiller University Jena  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Lopez\u2010Otin C","year":"2013","journal-title":"Cell"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000450","article-title":"Widespread protein aggregation as an inherent part of aging in C. 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