{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:49:54Z","timestamp":1791805794425,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2024\u2010ER2202\u201002"],"award-info":[{"award-number":["2024\u2010ER2202\u201002"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000207959"],"award-info":[{"award-number":["RS\u20102023\u201000207959"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102026\u201025474289"],"award-info":[{"award-number":["RS\u20102026\u201025474289"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Gram\u2010negative bacteria produce nonulosonic acids, a family of nine\u2010carbon sugars that mimic host sialic acids and may contribute to bacterial virulence. The nonulosonic acid C8\u2010epimeric 5,7\u2010di\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyllegionaminic acid (8\u2010epi\u2010Leg5,7Ac2) is a component of the K\u2010locus 49 (KL49) capsule of hypervirulent\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    , and its epimerization is proposed to be mediated by ElaA, ElaB, and ElaC. We identified a KL49 strain that induces lethal sepsis in mice and found deletion of\n                    <jats:italic>elaA<\/jats:italic>\n                    ,\n                    <jats:italic>elaB<\/jats:italic>\n                    , or\n                    <jats:italic>elaC<\/jats:italic>\n                    abolished lethality and markedly reduced capsule production. Crystal structures of ElaB, ElaA, and ElaC revealed conserved\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acetyl recognition underlying CMP\u2010Leg5,7Ac2 synthesis and regioselective C8 epimerization. Together, these genetic, structural, and\n                    <jats:italic>in vivo<\/jats:italic>\n                    findings identify ElaABC as potential antivirulence targets in emerging hypervirulent KL49\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    strains.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70390","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:17:06Z","timestamp":1781687826000},"page":"2947-2960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural insights and therapeutic targets in\n                    <i>Acinetobacter baumannii<\/i>\n                    capsule biosynthesis"],"prefix":"10.1002","volume":"600","author":[{"given":"Woo Cheol","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Gwangjin\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Gwangjin\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Yeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Gwangjin\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Gwangjin\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Bio\u2010Convergence Dankook University  Cheonan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Kyungpook National University  Jung\u2010gu Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"AI Molecular Design Team, New Drug Development Center Daegu Gyeongbuk Medical Innovation Foundation (K\u2010MEDI hub)  Dong\u2010gu Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6438-4718","authenticated-orcid":false,"given":"Yangmee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology Konkuk University  Gwangjin\u2010gu Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00181\u201019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00078\u201015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049\u2010632X.12033"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00366\u201010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00367\u201008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ225"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy691"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00944\u201013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08643"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S278891"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2025.109646"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2014.03.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/009480\u20100"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.148"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058\u201016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwv007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01360"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01412"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.08.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859\u2010023\u201005311\u20102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae268"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106150\u20103\u201038"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03975\u201014"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20109118\u20101_21"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047337"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444913022750"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"},{"key":"e_1_2_9_31_1","unstructured":"Schrodinger LLC(2015)\u201cThe PyMOL Molecular Graphics System Version 2.3ed.^eds.\u201d"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg556"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14826.1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00197\u201018"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000878"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000339"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004966"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00712\u201011"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2022.02.003"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2024.09.017"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2877"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi400821s"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi101871f"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja056490i"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5805"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi010737g"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00345\u201015"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04249"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001034\u20100"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70390","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/1873-3468.70390","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/1873-3468.70390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:30:50Z","timestamp":1791804650000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.70390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":48,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/1873-3468.70390"],"URL":"https:\/\/doi.org\/10.1002\/1873-3468.70390","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}