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Lectins\u2014glycan\u2010binding proteins\u2014play a dual role in this process: they interpret tumor\u2010associated glycan patterns and can also be exploited as therapeutic tools. In this review, we discuss emerging strategies that harness lectins in cancer immunotherapy. Engineered lectin\u2010based constructs, including antibody\u2013lectin chimeras, lectin\u2013drug conjugates, and glycan\u2010targeting CAR\u2010T cells, enable recognition of tumor\u2010specific glycosylation signatures. At the same time, endogenous lectin pathways such as the galectin\u2010polyLacNAc and sialic acid\u2010Siglec axes function as glyco\u2010immune checkpoints that suppress anti\u2010tumor responses and represent promising therapeutic targets. 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