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Among different types of autophagy, mitophagy or the selective autophagic clearance of dysfunctional mitochondria has emerged as particularly relevant in pancreatic \u03b2\u2010cell biology and its pathophysiology. Recent advances in functional genomics and animal studies implicate the autophagy\/mitophagy pathway components as effector transcripts at diabetes risk loci, providing a new rationale for investigation of genetic determinants of autophagy\/mitophagy in \u03b2 cells. In this review, we take a \u03b2\u2010cell centric perspective to examine the evidence for autophagy\/mitophagy across four clinically relevant diabetes categories (type 1, type 2, gestational, and monogenic diabetes) and discuss the functional significance and complexity of these pathways in \u03b2\u2010cell failure.<\/jats:p>","DOI":"10.1002\/1873-3468.70436","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:15:47Z","timestamp":1787138147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autophagy and mitophagy in pancreatic \u03b2\u2010cell homeostasis and their involvement in diabetes pathophysiology"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9617-4520","authenticated-orcid":false,"given":"Yunkyeong","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics Stanford University School of Medicine  CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-5108","authenticated-orcid":false,"given":"Mingming","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Genetics Stanford University School of Medicine  CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1205-1844","authenticated-orcid":false,"given":"Anna L.","family":"Gloyn","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics Stanford University School of Medicine  CA USA"},{"name":"Department of Genetics Stanford University School of Medicine  CA USA"},{"name":"Stanford Diabetes Research Center Stanford University School of Medicine  CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41574-025-01132-w","article-title":"Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation","volume":"21","author":"Ortega HI","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41574-025-01128-6","article-title":"Type 1 diabetes mellitus prevention: present and future","volume":"21","author":"Henriques FL","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-026-00687-w","article-title":"Type 2 diabetes mellitus","volume":"12","author":"Davies MJ","year":"2026","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.2337\/dci20-0065","article-title":"Monogenic diabetes: from genetic insights to population\u2010based precision in care. 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