{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:33:26Z","timestamp":1786534406285,"version":"build-2736575974"},"reference-count":131,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270416"],"award-info":[{"award-number":["82270416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470459"],"award-info":[{"award-number":["82470459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"abstract":"<jats:p>\n                    The L\u2010type calcium channel Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2 serves as a core trigger for excitation\u2010contraction and excitation\u2010transcription coupling in cardiovascular cells. Its abnormalities are closely linked to multiple cardiovascular diseases, including hypertension, arrhythmias, and cardiac hypertrophy. Alternative splicing (AS) generates Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2 channel isoforms with distinct electrophysiological properties and drug sensitivity, finely tuning channel functions. This review systematically summarizes AS regulation and pathological significance of Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2 in the cardiovascular system. Three key splicing events, mutually exclusive exons 8\/8a, cassette exon 9* and exon 33, impact channel gating, calcium influx, and drug responsiveness. These AS events are dynamically regulated by splicing factors such as Rbfox1\/2, PTBP1, and RBM20. We further analyze aberrant Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2 splicing in hypertension, heart failure, myocardial infarction, and diabetic cardiomyopathy. Finally, we discuss preclinical and clinical advances of antisense oligonucleotides for treating cardiovascular Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2 channelopathies. This review aims to clarify the regulatory network of Ca\n                    <jats:sub>V<\/jats:sub>\n                    1.2 AS, providing theoretical evidence for precision therapies based on splicing modulation.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70437","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T10:51:10Z","timestamp":1786531870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alternative splicing of the\n                    <scp>\n                      Ca\n                      <sub>V<\/sub>\n                      1\n                    <\/scp>\n                    .2 calcium channel and its role in cardiovascular diseases"],"prefix":"10.1002","author":[{"given":"Chenhao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehan","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Medical Imaging Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-5451","authenticated-orcid":false,"given":"Juejin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine Nanjing Medical University  Jiangsu China"},{"name":"The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine Nanjing Medical University  Taizhou Jiangsu China"},{"name":"Department of Rehabilitation, Jiangsu Province People's Hospital The First Affiliated Hospital of Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"I3","article-title":"History of calcium antagonists","volume":"52","author":"Fleckenstein A","year":"1983","journal-title":"Circ Res"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.cellbio.16.1.521","article-title":"Structure and regulation of voltage\u2010gated Ca2+ channels","volume":"16","author":"Catterall WA","year":"2000","journal-title":"Annu Rev Cell Dev Biol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.123.4.949","article-title":"Identification and differential subcellular localization of the neuronal class C and class D L\u2010type calcium channel alpha 1 subunits","volume":"123","author":"Hell JW","year":"1993","journal-title":"J Cell Biol"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"40837","DOI":"10.1074\/jbc.M307598200","article-title":"Enhanced expression of L\u2010type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2\u2010deficient mice","volume":"278","author":"Xu M","year":"2003","journal-title":"J Biol Chem"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"35133","DOI":"10.1074\/jbc.M705478200","article-title":"A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state\u2010dependent inhibition by nifedipine","volume":"282","author":"Liao P","year":"2007","journal-title":"J Biol Chem"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109262","article-title":"CACNA1C (Ca(V)1.2) and other L\u2010type calcium channels in the pathophysiology and treatment of psychiatric disorders: advances from functional genomics and pharmacoepidemiology","volume":"220","author":"Harrison PJ","year":"2022","journal-title":"Neuropharmacology"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cardiores.2005.06.024","article-title":"Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles","volume":"68","author":"Liao P","year":"2005","journal-title":"Cardiovasc Res"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/368067a0","article-title":"Calcium channel beta\u2010subunit binds to a conserved motif in the I\u2010II cytoplasmic linker of the alpha 1\u2010subunit","volume":"368","author":"Pragnell M","year":"1994","journal-title":"Nature"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1119729","article-title":"\u0392 subunits of voltage\u2010gated calcium channels in cardiovascular diseases","volume":"10","author":"Loh KWZ","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1152\/physrev.00022.2021","article-title":"Mechanisms and physiological implications of cooperative gating of clustered ion channels","volume":"102","author":"Dixon RE","year":"2022","journal-title":"Physiol Rev"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1085\/jgp.201912327","article-title":"A stochastic model of ion channel cluster formation in the plasma membrane","volume":"151","author":"Sato D","year":"2019","journal-title":"J Gen Physiol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"11109","DOI":"10.1074\/jbc.M117.784355","article-title":"Proteolytic cleavage of the hydrophobic domain in the Ca(V)\u03b12\u03b41 subunit improves assembly and activity of cardiac Ca(V)1.2 channels","volume":"292","author":"Segura E","year":"2017","journal-title":"J Biol Chem"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1113\/jphysiol.2002.018515","article-title":"Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells","volume":"541","author":"Colecraft HM","year":"2002","journal-title":"J Physiol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1152\/physrev.00057.2009","article-title":"The \u00df subunit of voltage\u2010gated Ca2+ channels","volume":"90","author":"Buraei Z","year":"2010","journal-title":"Physiol Rev"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"G154","DOI":"10.1152\/ajpgi.00393.2010","article-title":"Chronic stress targets posttranscriptional mechanisms to rapidly upregulate \u03b11C\u2010subunit of Cav1.2b calcium channels in colonic smooth muscle cells","volume":"300","author":"Li Q","year":"2011","journal-title":"Am J Physiol Gastrointest Liver 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the developing rat heart","volume":"163","author":"Vornanen M","year":"1996","journal-title":"Mol Cell Biochem"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/0008-6363(96)00083-1","article-title":"Contribution of sarcolemmal calcium current to total cellular calcium in postnatally developing rat heart","volume":"32","author":"Vornanen M","year":"1996","journal-title":"Cardiovasc Res"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010026\u201001286\u20108"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1161\/CIRCRESAHA.111.264028","article-title":"A caveolae\u2010targeted L\u2010type Ca2+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility","volume":"110","author":"Makarewich CA","year":"2012","journal-title":"Circ Res"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1172\/JCI58227","article-title":"Decreased 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hyperglycemia","volume":"129","author":"Syed AU","year":"2019","journal-title":"J Clin Invest"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"H127","DOI":"10.1152\/ajpheart.00168.2015","article-title":"Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor","volume":"309","author":"Pires PW","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cell.2004.09.011","article-title":"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism","volume":"119","author":"Splawski I","year":"2004","journal-title":"Cell"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.hrthm.2022.08.021","article-title":"Disrupted Ca(V)1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C\u2010E1115K iPS cell model","volume":"20","author":"Kashiwa A","year":"2023","journal-title":"Heart Rhythm"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1093\/europace\/euu063","article-title":"Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes","volume":"16","author":"Fukuyama M","year":"2014","journal-title":"Europace"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.hrthm.2021.12.032","article-title":"Role of CACNA1C in Brugada syndrome: prevalence and phenotype of probands referred for genetic testing","volume":"19","author":"Novelli V","year":"2022","journal-title":"Heart Rhythm"},{"key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"14619","DOI":"10.1038\/s41598-018-32867-4","article-title":"An African loss\u2010of\u2010function CACNA1C variant p.T1787M associated with a risk of ventricular fibrillation","volume":"8","author":"Blancard M","year":"2018","journal-title":"Sci Rep"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.hrthm.2010.08.026","article-title":"Mutations in the cardiac L\u2010type calcium channel associated with inherited J\u2010wave syndromes and sudden cardiac death","volume":"7","author":"Burashnikov E","year":"2010","journal-title":"Heart Rhythm"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/CIRCULATIONAHA.106.668392","article-title":"Loss\u2010of\u2010function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST\u2010segment elevation, short QT intervals, and sudden cardiac death","volume":"115","author":"Antzelevitch C","year":"2007","journal-title":"Circulation"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2115140118","article-title":"De novo mutations in childhood cases of sudden unexplained death that disrupt intracellular Ca(2+) regulation","volume":"118","author":"Halvorsen M","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41580-022-00545-z","article-title":"The physiology of alternative splicing","volume":"24","author":"Marasco LE","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41576-022-00556-8","article-title":"Regulation of pre\u2010mRNA splicing: roles in physiology and disease, and therapeutic prospects","volume":"24","author":"Rogalska ME","year":"2023","journal-title":"Nat Rev Genet"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","article-title":"Deep surveying of alternative splicing complexity in the human transcriptome by high\u2010throughput sequencing","volume":"40","author":"Pan Q","year":"2008","journal-title":"Nat Genet"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature07509","article-title":"Alternative isoform regulation in human tissue transcriptomes","volume":"456","author":"Wang ET","year":"2008","journal-title":"Nature"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"44335","DOI":"10.1074\/jbc.M407023200","article-title":"Transcript scanning reveals novel and extensive splice variations in human l\u2010type voltage\u2010gated calcium channel, Cav1.2 alpha1 subunit","volume":"279","author":"Tang ZZ","year":"2004","journal-title":"J Biol Chem"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1161\/ATVBAHA.120.315010","article-title":"Aberrant exon 8\/8a splicing by downregulated PTBP (Polypyrimidine tract\u2010binding protein) 1 increases Ca(V)1.2 Dihydropyridine resistance to attenuate vasodilation","volume":"40","author":"Lei J","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"e_1_2_9_43_1","first-page":"E4288","article-title":"Exclusion of alternative exon 33 of Ca(V)1.2 calcium channels in heart is proarrhythmogenic","volume":"114","author":"Li G","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/CIRCRESAHA.111.248849","article-title":"Splice variant specific modulation of CaV1.2 calcium channel by galectin\u20101 regulates arterial constriction","volume":"109","author":"Wang J","year":"2011","journal-title":"Circ Res"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/HYPERTENSIONAHA.117.09301","article-title":"Aberrant splicing induced by dysregulated Rbfox2 produces enhanced function of Ca(V)1.2 Calcium Channel and vascular myogenic tone in hypertension","volume":"70","author":"Zhou Y","year":"2017","journal-title":"Hypertension"},{"key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/j.1476-5381.2010.00798.x","article-title":"Alternative splicing modulates diltiazem sensitivity of cardiac and vascular smooth muscle Ca(v)1.2 calcium channels","volume":"160","author":"Zhang HY","year":"2010","journal-title":"Br J Pharmacol"},{"key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/01.RES.81.4.526","article-title":"Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue\u2010specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L\u2010type Ca2+ channels","volume":"81","author":"Welling A","year":"1997","journal-title":"Circ Res"},{"key":"e_1_2_9_48_1","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1111\/febs.17159","article-title":"Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia\u2010induced Ca(v)1.2 splicing and RbFox1\/Fox2 downregulation","volume":"291","author":"Poore CP","year":"2024","journal-title":"FEBS J"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1073\/pnas.89.4.1497","article-title":"Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart","volume":"89","author":"Diebold RJ","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1074\/jbc.M114.594911","article-title":"Alternative splicing generates a novel truncated Cav1.2 channel in neonatal rat heart","volume":"290","author":"Liao P","year":"2015","journal-title":"J Biol Chem"},{"key":"e_1_2_9_51_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep35247","article-title":"Aberrant splicing promotes proteasomal degradation of L\u2010type Ca(V)1.2 calcium channels by competitive binding for Ca(V)\u03b2 subunits in cardiac hypertrophy","volume":"6","author":"Hu Z","year":"2016","journal-title":"Sci Rep"},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41380-019-0583-1","article-title":"Long\u2010read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain","volume":"25","author":"Clark MB","year":"2020","journal-title":"Mol Psychiatry"},{"key":"e_1_2_9_53_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbadis.2018.08.016","article-title":"Galectin\u20101 attenuates cardiomyocyte hypertrophy through splice\u2010variant specific modulation of Ca(V)1.2 calcium channel","volume":"1865","author":"Fan J","year":"2019","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"e_1_2_9_54_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yjmcc.2025.11.011","article-title":"Impaired retinoic acid signaling mediated Rbm20 downregulation induces aberrant splicing of Ca(V)1.2 calcium channel: implications in myocardial hypertrophy","volume":"211","author":"Song X","year":"2026","journal-title":"J Mol Cell Cardiol"},{"key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1113\/jphysiol.2003.052712","article-title":"The impact of splice isoforms on voltage\u2010gated calcium channel alpha1 subunits","volume":"554","author":"Jurkat\u2010Rott K","year":"2004","journal-title":"J Physiol"},{"key":"e_1_2_9_56_1","doi-asserted-by":"crossref","first-page":"22100","DOI":"10.1074\/jbc.M101469200","article-title":"Alpha 1D (Cav1.3) subunits can form l\u2010type Ca2+ channels activating at negative voltages","volume":"276","author":"Koschak A","year":"2001","journal-title":"J Biol Chem"},{"key":"e_1_2_9_57_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0014-5793(98)00425-6","article-title":"Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene","volume":"427","author":"Z\u00fchlke RD","year":"1998","journal-title":"FEBS Lett"},{"key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/molehr\/5.4.311","article-title":"Identification of structural elements of the testis\u2010specific voltage dependent calcium channel that potentially regulate its biophysical properties","volume":"5","author":"Goodwin LO","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"e_1_2_9_59_1","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1073\/pnas.0502506102","article-title":"Severe arrhythmia disorder caused by cardiac L\u2010type calcium channel mutations","volume":"102","author":"Splawski I","year":"2005","journal-title":"Proc Natl\u00a0Acad Sci USA"},{"key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/ajmg.a.36924","article-title":"Expanding the phenotype of Timothy syndrome type 2: an adolescent with ventricular fibrillation but normal development","volume":"167","author":"Hiippala A","year":"2015","journal-title":"Am J Med Genet A"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"50329","DOI":"10.1074\/jbc.M409436200","article-title":"Smooth muscle\u2010selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels","volume":"279","author":"Liao P","year":"2004","journal-title":"J Biol Chem"},{"key":"e_1_2_9_62_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12933-023-01894-5","article-title":"Dysregulated Rbfox2 produces aberrant splicing of Ca(V)1.2 calcium channel in diabetes\u2010induced cardiac hypertrophy","volume":"22","author":"Li P","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"H1820","DOI":"10.1152\/ajpheart.00326.2009","article-title":"Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameter","volume":"297","author":"Nystoriak 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