{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:58:56Z","timestamp":1788479936490,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK144025"],"award-info":[{"award-number":["P30DK144025"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK114356"],"award-info":[{"award-number":["R01DK114356"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK138018"],"award-info":[{"award-number":["R01DK138018"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK139397"],"award-info":[{"award-number":["R01DK139397"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"abstract":"<jats:p>\n                    Higher levels of plasminogen activator inhibitor\u20101 (PAI\u20101) circulate in the blood of people with obesity and predict hyperlipidemia and metabolic dysfunction\u2010associated steatotic liver disease in studies predominantly conducted in women. To understand the roles of PAI\u20101 in women with obesity, we generated inducible whole\u2010body PAI\u20101\u2010depleted female mice (\n                    <jats:italic>Pai\u20101<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>i\u2010KD<\/jats:italic>\n                    <\/jats:sup>\n                    ). After high\u2010fat diet feeding,\n                    <jats:italic>Pai\u20101<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>i\u2010KD<\/jats:italic>\n                    <\/jats:sup>\n                    and littermate controls did not differ in body weight or energy balance. However,\n                    <jats:italic>Pai\u20101<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>i\u2010KD<\/jats:italic>\n                    <\/jats:sup>\n                    females accumulated smaller inguinal WAT adipocytes. Spectral flow cytometry revealed reduced adipocyte progenitors and macrophages in inguinal WAT.\n                    <jats:italic>Pai\u20101<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>i\u2010KD<\/jats:italic>\n                    <\/jats:sup>\n                    mice also exhibited decreased liver cholesterol. These preclinical findings argue that elevated PAI\u20101 alters subcutaneous adipose tissue biology and contributes to pathogenic phenotypes of obesity.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70439","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:41:46Z","timestamp":1787377306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Partial depletion of plasminogen activator inhibitor\u20101 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high\u2010fat\u2010fed female mice"],"prefix":"10.1002","author":[{"given":"Claudia E.","family":"Ramirez Bustamante","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sharp","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradip K.","family":"Saha","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Anaya","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L.","family":"Lieu","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn L.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jeong","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care, and Pain Medicine, McGovern Medical School University of Texas Health Science Center at Houston  TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Cox","sequence":"additional","affiliation":[{"name":"Center for Metabolic and Degenerative Diseases, the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases University of Texas Health Science Center at Houston  TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care, and Pain Medicine, McGovern Medical School University of Texas Health Science Center at Houston  TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-2072","authenticated-orcid":false,"given":"Sean M.","family":"Hartig","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine Baylor College of Medicine  Houston TX USA"},{"name":"Department of Molecular and Cellular Biology Baylor College of Medicine  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25\u2009years","volume":"377","author":"Global Burden of Disease Collaborators","year":"2017","journal-title":"N Engl J Med"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: facts and fantasies","volume":"129","author":"Smith GI","year":"2019","journal-title":"J Clin Invest"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.metabol.2018.11.009","article-title":"Metabolically healthy versus\u00a0metabolically unhealthy obesity","volume":"92","author":"Iacobini 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