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Among the systems most affected, the gut and liver are particularly important because of their role in metabolism, detoxification, and immune regulation. These two organs are closely connected through the portal vein and bile ducts, enabling continuous, bidirectional communication that coordinates homeostasis. Understanding how gut\u2013liver communication changes with age is therefore critical, as even subtle alterations over time can have widespread effects on overall physiology and the progression of age\u2010related disorders. In this review, we examine current knowledge on how aging shapes gut and liver physiology, highlighting changes in microbial composition, barrier function, and hepatic metabolism. We then discuss how sex influences the gut\u2013liver axis during aging. 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