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Increasing evidence, however, positions BRCA2 at the interface of transcription and replication, where it preserves genome stability under transcription\u2010associated stress. BRCA2 regulates R\u2010loop homeostasis, transcription\u2013replication conflict resolution, and RNA polymerase II dynamics. Its loss leads to R\u2010loop accumulation, transcriptional pausing, and elevated transcription\u2013replication head\u2010on collisions, particularly in highly transcribed regions. BRCA2 also promotes the processing of RNA\u2010associated DNA lesions, preventing toxic intermediates during S phase. Through interactions with factors such as PAF1, PCAF, and DDX5, BRCA2 coordinates transcription, chromatin regulation, and DNA\u2013RNA hybrid resolution, linking these processes to inflammatory and stress\u2010responsive transcriptional programs, including NF\u2010\u03baB signaling. In this review, we focus on the emerging roles of BRCA2 in transcription\u2010related pathways, including R\u2010loop homeostasis, resolution of transcription\u2013replication conflicts, RNA polymerase II dynamics, and broader transcriptional regulation.<\/jats:p>","DOI":"10.1002\/1873-3468.70461","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:47:58Z","timestamp":1791287278000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>RNA<\/scp>\n                    \u2010related functions of\n                    <scp>BRCA2<\/scp>\n                    in transcription, replication, and genome stability"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1437-5537","authenticated-orcid":false,"given":"Lucia","family":"Alvaro\u2010Aranda","sequence":"first","affiliation":[{"name":"Genome Instability and Cancer Predisposition Laboratory Centro de Biologia 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