{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:23:30Z","timestamp":1789115010892,"version":"build-2803163510"},"reference-count":171,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001852","name":"Indo-French Centre for the Promotion of Advanced Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007179","name":"Advanced Centre for Treatment, Research and Education in Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"abstract":"<jats:p>\n                    Aging causes disruption of tissue homeostasis, with stem cell exhaustion as a major hallmark. However, whether aging trajectories are established during development remains unexplored. Here, we demonstrate that genetic modulation of aging\u2010associated pathways in larval adult midgut progenitors (AMPs) determines the trajectory of\n                    <jats:italic>Drosophila<\/jats:italic>\n                    adult intestinal homeostasis. Induction of aging\u2010associated pathways in the AMPs results in aberrant proliferation, skewed differentiation, barrier dysfunction, and genomic instability. Ultimately, AMP islet architecture is destabilized and age\u2010related molecular signatures are altered. In contrast, reversing aging\u2010associated effects results in a decrease in the enteroendocrine population and the barrier is unaffected. Together, our findings demonstrate that aging\u2010associated pathways are tightly regulated during early development and perturbation can hamper adult gut homeostasis, establishing AMPs as key developmental determinants.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70462","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:26:21Z","timestamp":1789111581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Developmental regulation of progenitor aging shapes long\u2010term intestinal homeostasis in\n                    <i>Drosophila<\/i>"],"prefix":"10.1002","author":[{"given":"Shikha","family":"Malik","sequence":"first","affiliation":[{"name":"Stem Cell and Tissue Homeostasis Laboratory Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata\u00a0Memorial Centre  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atharva Anand","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Stem Cell and Tissue Homeostasis Laboratory Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata\u00a0Memorial Centre  Navi Mumbai India"},{"name":"Homi Bhabha National Institute Training School Complex, Anushakti Nagar  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saraswathi J.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Stem Cell and Tissue Homeostasis Laboratory Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata\u00a0Memorial Centre  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Shinde","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Training School Complex, Anushakti Nagar  Mumbai India"},{"name":"Computational Biology, Bioinformatics, and Crosstalk Lab Advanced Centre for Treatment, Research, and Education in Cancer  Navi\u00a0Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad","family":"Shameem","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering Indian Institute of Technology Bombay  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Pande","sequence":"additional","affiliation":[{"name":"Stem Cell and Tissue Homeostasis Laboratory Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata\u00a0Memorial Centre  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Chandrani","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute Training School Complex, Anushakti Nagar  Mumbai India"},{"name":"Computational Biology, Bioinformatics, and Crosstalk Lab Advanced Centre for Treatment, Research, and Education in Cancer  Navi\u00a0Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandar M.","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering Indian Institute of Technology Bombay  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-2736","authenticated-orcid":false,"given":"Rohan J.","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"Stem Cell and Tissue Homeostasis Laboratory Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata\u00a0Memorial Centre  Navi Mumbai India"},{"name":"Homi Bhabha National Institute Training School Complex, Anushakti Nagar  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-62043-y","article-title":"Age mosaic of gut epithelial 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