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GC B cells undergo extraordinary levels of proliferation, DNA damage, and apoptosis prior to differentiating to long\u2010lived memory or plasma cells, and ubiquitin pathways underpin these activities. Oncogenic gammaherpesviruses infect B cells and drive them through a GC activation program. Viral programs exploit ubiquitin biology to establish latency in GC B cells and persist for life in long\u2010lived memory B cells, poised to drive lymphomagenesis over time. Here, we will first define how ubiquitin regulates normal GC B cells. Within this framework, we will describe how gammaherpesviruses interact with these mechanisms to establish latency, highlighting common and divergent mechanisms of GC control in infected and normal B cells. Further understanding ubiquitin mechanisms in GC B cells will aid the discovery of highly specific molecular circuits that regulate B\u2010cell fate and function, with broad relevance to antiviral immunity and cancer biology.<\/jats:p>","DOI":"10.1002\/1873-3468.70470","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:46:51Z","timestamp":1789987611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The ubiquitin system in normal and infected germinal center B cells"],"prefix":"10.1002","author":[{"given":"Destiny","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Medicine University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesly","family":"Mejia","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Florida  Gainesville FL 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