{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:02:12Z","timestamp":1791198132597,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019921","name":"National Scleroderma Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100019921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR076938"],"award-info":[{"award-number":["AR076938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["FEBS Letters"],"abstract":"<jats:p>\n                    Skin fibrosis is marked by extracellular matrix accumulation and dermal white adipose tissue (DWAT), resulting in tissue stiffening. We show that sustained Wnt activation in mature dermal adipocytes induces lipodystrophy and promotes fibrotic remodeling via oxidative stress. Meta\u2010analysis of early systemic sclerosis skin transcriptomes reveals increased reactive oxygen species (ROS) production and lipid peroxidation. In cultured mouse dermal adipocytes, Wnt activation triggers a robust increase in ROS and lipid peroxidation, which is suppressed by scavengers.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , Wnt activation elevates oxidative stress in DWAT, and N\u2010acetyl\u2010L\u2010cysteine scavenger protects from DWAT lipodystrophy and dermal collagen accumulation. These findings identify a Wnt\u2013ROS\u2013lipid peroxidation axis as a key driver of lipodystrophy and skin fibrosis, highlighting a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1002\/1873-3468.70479","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:23:01Z","timestamp":1791195781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reactive oxygen species\u2010induced lipid peroxidation mediates Wnt\u2010dependent lipodystrophy and associated skin fibrosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4438-8133","authenticated-orcid":false,"given":"Qiannan","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Biology Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-585X","authenticated-orcid":false,"given":"Suneeti R.","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8924-9415","authenticated-orcid":false,"given":"Emilia","family":"Sanz\u2010Rios","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3778-6587","authenticated-orcid":false,"given":"Rachel","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-6552","authenticated-orcid":false,"given":"Radhika P.","family":"Atit","sequence":"additional","affiliation":[{"name":"Department of Biology Case Western Reserve University  Cleveland OH USA"},{"name":"Department of Genetics and Genome Sciences Case Western Reserve University  Cleveland OH USA"},{"name":"Department of Dermatology Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/BOR.0000000000000437","article-title":"The roles of dermal white adipose tissue loss in scleroderma skin fibrosis","volume":"29","author":"Marangoni RG","year":"2017","journal-title":"Curr Opin 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