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However, the clinical significance and mechanism of Plac1 in cancer progression remain elusive. Here, we report that Plac1 is an important oncogenic and prognostic factor, which physically interacts with Furin to drive breast cancer invasion and metastasis. We have shown that Plac1 expression positively correlates with clinical stage, lymph node metastasis, hormone receptor status, and overall patient survival. Overexpression of Plac1 promoted invasion and metastasis of breast cancer cells\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    and\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    . Co\u2010immunoprecipitation and immunofluorescence cell staining assays revealed that interaction of Plac1 and Furin degraded Notch1 and generated Notch1 intracellular domain (\n                    <jats:styled-content style=\"fixed-case\">NICD<\/jats:styled-content>\n                    ) that could inhibit\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    activity. These findings are consistent with the results of microarray study in\n                    <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>\n                    \u2010231 cells overexpressing Plac1. A rescue study showed that inhibition of Furin and overexpression of\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    in Plac1 overexpression cells blocked Plac1\u2010induced tumor cell progression. Taken together, our findings suggest that functional interaction between Plac1 and Furin enhances breast cancer invasion and metastasis and the Furin\/\n                    <jats:styled-content style=\"fixed-case\">NICD<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">PTEN<\/jats:styled-content>\n                    axis may act as an important therapeutic target for breast cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.12311","type":"journal-article","created":{"date-parts":[[2018,4,28]],"date-time":"2018-04-28T11:59:49Z","timestamp":1524916789000},"page":"1233-1248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Cancer\/testis antigen\u2010Plac1 promotes invasion and metastasis of breast cancer through Furin\/\n                    <scp>NICD<\/scp>\n                    \/\n                    <scp>PTEN<\/scp>\n               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