{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:01:57Z","timestamp":1792782117423,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government","award":["12111022"],"award-info":[{"award-number":["12111022"]}],"id":[{"id":"https:\/\/ror.org\/03qh32912","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    Cervical cancer is one of the leading causes of cancer death in women globally, despite the widespread use of cytology\/human papillomavirus (\n                    <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\n                    ) screening. In the present study, we aimed to identify the potential role of micro\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    (miRNA) as a diagnostic biomarker in the detection of cervical pre\u2010malignant lesions and cancer. In total, we recruited 582 patients with cervical diseases and 145 control individuals. The expression levels of six mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s (miR\u201020a, miR\u201092a, miR\u2010141, miR\u2010183*, miR\u2010210 and miR\u2010944) were found to be significantly up\u2010regulated in cervical cancer and pre\u2010malignant lesions compared to normal cervical samples, indicating that they are oncogenic mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s. Receiver operating characteristic curve analysis showed that these six mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s can be used to distinguish patients with cervical pre\u2010malignant lesions or cancer from normal individuals and they also had a good predictive performance, particularly in cervical lesions. Combined use of these six mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    s further enhanced the diagnostic accuracy over any single mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    marker, with an area under the curve of 0.998, 0.996 and 0.959, a diagnostic sensitivity of 97.9%, 97.2% and 91.4%, and a specificity of 98.6%, 96.6% and 87.6% for low\u2010grade lesions, high\u2010grade lesions and cancer, respectively. This six oncogenic mi\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    signature may be suitable for use as diagnostic marker for cervical pre\u2010malignant lesions and cancer in the near future.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.12383","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T03:25:02Z","timestamp":1537154702000},"page":"2009-2022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Oncogenic micro\n                    <scp>RNA<\/scp>\n                    signature for early diagnosis of cervical intraepithelial neoplasia and cancer"],"prefix":"10.1002","volume":"12","author":[{"given":"Stephanie S.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K. L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K. H.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina N.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley S. K.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siew F.","family":"Ngu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy M. Y.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Yu","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology LKS Faculty of Medicine The University of Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip P. 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