{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:22:52Z","timestamp":1792686172858,"version":"4.5.0"},"reference-count":197,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["20473"],"award-info":[{"award-number":["20473"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Squamous cell carcinoma (\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    ) is a treatment\u2010refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    of distinct origins. Some of these genetic events culminate in fostering the activity of \u0394Np63, a potent oncogene which exerts its pro\u2010tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying \u0394Np63 oncogenic activities in\n                    <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                    , and discuss some relevant transcriptional effectors of \u0394Np63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (\n                    <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.12473","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T12:32:53Z","timestamp":1551961973000},"page":"981-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["\u0394Np63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-7379","authenticated-orcid":false,"given":"Veronica","family":"Gatti","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine TOR University of Rome, Tor Vergata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-1254","authenticated-orcid":false,"given":"Claudia","family":"Fierro","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine TOR University of Rome, Tor Vergata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-4740","authenticated-orcid":false,"given":"Margherita","family":"Annicchiarico\u2010Petruzzelli","sequence":"additional","affiliation":[{"name":"Istituto Dermopatico dell'Immacolata IDI\u2010IRCCS Rome 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