{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:44:22Z","timestamp":1787244262263,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011692","name":"Children's Cancer and Leukaemia Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000849","name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["692180\u2010STREAMH2020\u2010TWINN\u20102015"],"award-info":[{"award-number":["692180\u2010STREAMH2020\u2010TWINN\u20102015"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2015\/18\/E\/NZ5\/00723"],"award-info":[{"award-number":["2015\/18\/E\/NZ5\/00723"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    B\u2010cell precursor acute lymphoblastic leukemia (BCP\u2010ALL) is a genetically heterogeneous blood cancer characterized by abnormal expansion of immature B cells. Although intensive chemotherapy provides high cure rates in a majority of patients, subtypes harboring certain genetic lesions, such as\n                    <jats:italic>MLL<\/jats:italic>\n                    rearrangements or\n                    <jats:italic>BCR\u2010ABL1<\/jats:italic>\n                    fusion, remain clinically challenging, necessitating a search for other therapeutic approaches. Herein, we aimed to validate antioxidant enzymes of the thioredoxin system as potential therapeutic targets in BCP\u2010ALL. We observed oxidative stress along with aberrant expression of the enzymes associated with the activity of thioredoxin antioxidant system in BCP\u2010ALL cells. Moreover, we found that auranofin and adenanthin, inhibitors of the thioredoxin system antioxidant enzymes, effectively kill BCP\u2010ALL cell lines and pediatric and adult BCP\u2010ALL primary cells, including primary cells cocultured with bone marrow\u2010derived stem cells. Furthermore, auranofin delayed the progression of leukemia in\n                    <jats:italic>MLL<\/jats:italic>\n                    \u2010rearranged patient\u2010derived xenograft model and prolonged the survival of leukemic NSG mice. Our results unveil the thioredoxin system as a novel target for BCP\u2010ALL therapy, and indicate that further studies assessing the anticancer efficacy of combinations of thioredoxin system inhibitors with conventional anti\u2010BCP\u2010ALL drugs should be continued.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.12476","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T13:35:04Z","timestamp":1552397704000},"page":"1180-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Targeting the thioredoxin system as a novel strategy against B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"13","author":[{"given":"Klaudyna","family":"Fidyt","sequence":"first","affiliation":[{"name":"Department of Immunology Medical University of Warsaw Poland"},{"name":"Postgraduate School of Molecular Medicine Medical University of Warsaw 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Pal","sequence":"additional","affiliation":[{"name":"Newcastle Cancer Centre at the Northern Institute for Cancer Research Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Blair","sequence":"additional","affiliation":[{"name":"Newcastle Cancer Centre at the Northern Institute for Cancer Research Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Burdzinska","sequence":"additional","affiliation":[{"name":"Department of Immunology, Transplantology and Internal Diseases Medical University of Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Pedzisz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Medical University of Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Glodkowska\u2010Mrowka","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age Medical University of Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Demkow","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age Medical University of Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5779-0822","authenticated-orcid":false,"given":"Karolina","family":"Gawle\u2010Krawczyk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hematology and Oncology Medical University of Warsaw 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