{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:06:50Z","timestamp":1790269610882,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2017\u2010I2M\u20104\u2010003"],"award-info":[{"award-number":["2017\u2010I2M\u20104\u2010003"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L172055"],"award-info":[{"award-number":["L172055"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>Most cases of hepatocellular carcinoma (HCC) are already advanced at the time of diagnosis, which limits treatment options. Challenges in early\u2010stage diagnosis may be due to the genetic complexity of HCC. Gene fusion plays a critical function in tumorigenesis and cancer progression in multiple cancers, yet the identities of fusion genes as potential diagnostic markers in HCC have not been investigated. Here, we employed STAR\u2010Fusion and identified 43 recurrent fusion events in our own and four public RNA\u2010seq datasets. We identified 2354 different gene fusions in two hepatitis B virus (HBV)\u2010HCC patients. Validation analysis against the four RNA\u2010seq datasets revealed that only 1.8% (43\/2354) were recurrent fusions. Comparison with the four fusion databases demonstrated that 19 recurrent fusions were not previously annotated to diseases and three were annotated as disease\u2010related fusion events. Finally, we validated six of the novel fusion events, including RP11\u2010476K15.1\u2010CTD\u20102015H3.2, by RT\u2010PCR and Sanger sequencing of 14 pairs of HBV\u2010related HCC samples. In summary, our study provides new insights into gene fusions in HCC and may contribute to the development of anti\u2010HCC therapy.<\/jats:p>","DOI":"10.1002\/1878-0261.12479","type":"journal-article","created":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T09:00:37Z","timestamp":1553331637000},"page":"1214-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The fusion landscape of hepatocellular carcinoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Chengpei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangcai","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"My Health Gene Technology Co., Ltd. Service Centre of Tianjin Chentang Science and Technology Commercial District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"My Health Gene Technology Co., Ltd. Service Centre of Tianjin Chentang Science and Technology Commercial District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"My Health Gene Technology Co., Ltd. Service Centre of Tianjin Chentang Science and Technology Commercial District China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Robson","sequence":"additional","affiliation":[{"name":"Liver Center and The Transplant Institute Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghai","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"My Health Gene Technology Co., Ltd. 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