{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:15:39Z","timestamp":1786976139313,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["febs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Oncology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>\n                    Metastasis\u2010associated in colon cancer 1 (\n                    <jats:styled-content style=\"fixed-case\">MACC<\/jats:styled-content>\n                    1) and S100 calcium\u2010binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of\n                    <jats:styled-content style=\"fixed-case\">MACC<\/jats:styled-content>\n                    1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer.\n                    <jats:styled-content style=\"fixed-case\">MACC<\/jats:styled-content>\n                    1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by\n                    <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>\n                    and digital droplet\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    , respectively.\n                    <jats:styled-content style=\"fixed-case\">MACC<\/jats:styled-content>\n                    1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.024;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). At primary diagnosis, high levels of\n                    <jats:styled-content style=\"fixed-case\">MACC<\/jats:styled-content>\n                    1 or S100A4 correlated with advanced\n                    <jats:styled-content style=\"fixed-case\">FIGO<\/jats:styled-content>\n                    stage (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.042;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.008), predicted suboptimal debulking surgery and indicated shorter progression\u2010free survival (\n                    <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\n                    ;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.003;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.001) and overall survival (\n                    <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                    ;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.001;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.002). This is the first study in ovarian cancer to propose circulating\n                    <jats:styled-content style=\"fixed-case\">MACC<\/jats:styled-content>\n                    1 and S100A4 transcripts as potential liquid biopsy markers.\n                  <\/jats:p>","DOI":"10.1002\/1878-0261.12484","type":"journal-article","created":{"date-parts":[[2019,3,30]],"date-time":"2019-03-30T10:54:36Z","timestamp":1553943276000},"page":"1268-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Clinical relevance of circulating\n                    <scp>MACC<\/scp>\n                    1 and S100A4 transcripts for ovarian cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Theresa","family":"Link","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany; Helmholtz\u2010Zentrum Dresden \u2013 Rossendorf (HZDR) Dresden Germany"},{"name":"German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Dominik","family":"Kuhlmann","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany; Helmholtz\u2010Zentrum Dresden \u2013 Rossendorf (HZDR) Dresden Germany"},{"name":"German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Kobelt","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlinand Max\u2010Delbr\u00fcck\u2010Center for Molecular Medicine in the Helmholtz Association Berlin Germany"},{"name":"German Cancer Consortium (DKTK) Berlin and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlinand Max\u2010Delbr\u00fcck\u2010Center for Molecular Medicine in the Helmholtz Association Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana D.","family":"Vassileva","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany; Helmholtz\u2010Zentrum Dresden \u2013 Rossendorf (HZDR) Dresden Germany"},{"name":"German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kramer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I Medical Faculty and University Hospital Technische Universit\u00e4t Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Frank","sequence":"additional","affiliation":[{"name":"DRK\u2010Blood Donor Service ITM Plauen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"G\u00f6ckenjan","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany; Helmholtz\u2010Zentrum Dresden \u2013 Rossendorf (HZDR) Dresden Germany"},{"name":"German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Wimberger","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty University Hospital Carl Gustav Carus Technische Universit\u00e4t Dresden Germany"},{"name":"National Center for Tumor Diseases (NCT), Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, Dresden, Germany; Helmholtz\u2010Zentrum Dresden \u2013 Rossendorf (HZDR) Dresden Germany"},{"name":"German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ) Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Stein","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlinand Max\u2010Delbr\u00fcck\u2010Center for 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